Abstract

The NYU Kaplan Comprehensive Cancer Center is an interdisciplinary and interdepartmental program designed to foster, enhance and coordinate the conduct of oncology research, education and patient care activity at NYU Medical Center. Gaining comprehensive status in 1991 and merging with the cancer center of the Institute of Environmental Medicine in 1992, the Center now represents the total spectrum of the institution's cancer activities. Its membership consists of NYU medical school faculty actively engaged in cancer research at all levels of investigation. The Center promotes through its program orientation and specialized shared resource units, the collaboration and technology transfer intended to more rapidly translate the benefits of research into more effective approaches to cancer. A broad range of oncology research is being conducted at the Center through nine program units and the support of seventeen shared resources. The Center places particular emphasis on elucidating the molecular and genetic events responsible for cellular transformation; the host defense mechanisms which regulate the immune response; the etiologic agents within the environment which cause or contribute to cancer; and the therapies and prevention which will prove to be more effective.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016087-17
Application #
2086436
Study Section
Cancer Center Support Review Committee (CCS)
Project Start
1975-06-30
Project End
1995-11-30
Budget Start
1994-02-15
Budget End
1994-11-30
Support Year
17
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Saint Fleur-Lominy, Shella; Maus, Mate; Vaeth, Martin et al. (2018) STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Rep 24:3045-3060.e5
Puranik, Amrutesh S; Leaf, Irina A; Jensen, Mark A et al. (2018) Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Sci Rep 8:13948
Weng, Mao-Wen; Lee, Hyun-Wook; Park, Sung-Hyun et al. (2018) Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis. Proc Natl Acad Sci U S A 115:E6152-E6161
Cui, Xin; Morales, Renee-Tyler Tan; Qian, Weiyi et al. (2018) Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis. Biomaterials 161:164-178
Burgess, Hannah M; Pourchet, Aldo; Hajdu, Cristina H et al. (2018) Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus. Mol Ther Oncolytics 8:71-81
Wong, Serre-Yu; Coffre, Maryaline; Ramanan, Deepshika et al. (2018) B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. J Immunol 201:1442-1451
Handler, Jesse; Cullis, Jane; Avanzi, Antonina et al. (2018) Pre-neoplastic pancreas cells enter a partially mesenchymal state following transient TGF-? exposure. Oncogene 37:4334-4342
Diamond, Julie M; Vanpouille-Box, Claire; Spada, Sheila et al. (2018) Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. Cancer Immunol Res 6:910-920
Fan, Xiaozhou; Peters, Brandilyn A; Jacobs, Eric J et al. (2018) Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults. Microbiome 6:59
Chen, Danqi; Fang, Lei; Mei, Shenglin et al. (2018) Erratum: ""Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells"". Environ Health Perspect 126:019001

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