The objective of the Experimental Animal and Exposure Core Facility is to provide a highly specializedshared resource to support the scientific needs of members of the NYU Cancer Institute for cancer-relatedanimal research in carcinogenesis models and in carcinogen administration. The facility consists of twontegrated units, the Animal Care and Exposure Unit and the Inhalation Exposure Unit, which providesspecialized animal care, technical assistance for experiments with rodent species involving delivery ofcarcinogenic and toxic chemicals, infectious agents for challenge experiments, or intervention compoundsfor chemoprevention or chemotherapy via various routes of exposure including inhalation, systemic, dermal,and oral administration. In addition, several radiation equipments for skin irradiation of laboratory animalswith electrons, UV and X-ray are also available. The Animal Care and Exposure Unit and the InhalationExposure Unit of the resource provide unique services that are not offered elsewhere at NYU School ofMedicine; in fact, the Inhalation Exposure Unit is one of the largest academic facilities of its kind. We provideexpertise in experimental design and conduct for cancer-related animal studies and necropsy services foranimal experiments. Another unique service we provide is segregated housing and health monitoring ofanimals that do not yet have a proven virus antibody-free (VAF) status or that carry transplantable tumorsthat have not yet been MAP tested; work with these types of animals allows feasibility or pilot studies andsmall experiments with these animals. By providing comprehensive scientific consultation and collaborationon carcinogenesis animal models and carcinogen exposure, our primary goal is to facilitate and enhancescientific interaction and productivity among NYUCI investigators. This shared resource is available to allmembers of the NYU Cancer Institute and other members of the NYU community, but Cancer Institutemembers have priority over nonmembers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016087-28
Application #
7714207
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-04-18
Project End
2013-02-28
Budget Start
2008-04-18
Budget End
2009-02-28
Support Year
28
Fiscal Year
2008
Total Cost
$41,427
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Pelzek, Adam J; Shopsin, Bo; Radke, Emily E et al. (2018) Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection. MBio 9:
Chiou, Kenneth L; Bergey, Christina M (2018) Methylation-based enrichment facilitates low-cost, noninvasive genomic scale sequencing of populations from feces. Sci Rep 8:1975
Jose, Cynthia C; Jagannathan, Lakshmanan; Tanwar, Vinay S et al. (2018) Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1. Mol Carcinog 57:794-806
Kourtis, Nikos; Lazaris, Charalampos; Hockemeyer, Kathryn et al. (2018) Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nat Med 24:1157-1166
Formenti, Silvia C; Lee, Percy; Adams, Sylvia et al. (2018) Focal Irradiation and Systemic TGF? Blockade in Metastatic Breast Cancer. Clin Cancer Res 24:2493-2504
Snuderl, Matija; Kannan, Kasthuri; Pfaff, Elke et al. (2018) Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. Nat Commun 9:2868
Stafford, James M; Lee, Chul-Hwan; Voigt, Philipp et al. (2018) Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Sci Adv 4:eaau5935
Lee, Chul-Hwan; Yu, Jia-Ray; Kumar, Sunil et al. (2018) Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin. Mol Cell 70:422-434.e6
Aiello, Nicole M; Maddipati, Ravikanth; Norgard, Robert J et al. (2018) EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Dev Cell 45:681-695.e4
Jung, Heekyung; Baek, Myungin; D'Elia, Kristen P et al. (2018) The Ancient Origins of Neural Substrates for Land Walking. Cell 172:667-682.e15

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