The Genitourinary Oncology Program consists of a group of basic and clinical investigators collectively focused upon the study and treatment of genitourinary malignancies. The goals of the program include optimal multidisciplinary care through interaction of clinicians of various disciplines, understanding disease biology through the study of basic mechanisms of carcinogenesis and tumor progression, advancement of clinical care through effective implementation of clinical trials, and development of novel preventive and therapeutic strategies through collaboration of basic investigators and clinicians. The program facilitates the achievement of its goals through inter-programmatic seminars and conferences, provision of access to cancer center core facilities and program resources, and acting to identify additional opportunities to maximize the success of collaborations and individual program members. Historically, the main clinical focus of the NYU GU Oncology program has been prostate cancer due to the Department of Urology's longstanding clinical focus in the disease, the large volume of patients, and the number of basic investigators focused in the disease. This remains the most well-developed focus of the program. In the area of bladder cancer, the NYU program has a strong basic research group focused in urothelial biology and urothelial carcinogenesis. While there are ongoing clinical trials in bladder cancer, the program continues to seek additional physician scientists focused in the area of translational and clinical research in bladder cancer. At present, there are 27 program members with appointments in 12 departments within the medical school. 15/27 members are primarily focused in the area of prostate cancer, while 6/27 are focused in trie study of urothelial cancer. The group consists of 9 clinician scientists, 13 basic investigators, and one statistician. Total NCI funding has increased from $1,377,698 to $1,708,288. Membership has increased from 24 to 27. Total publications over the past five years total 211 of which 18% are intra-programmatic and 10% are interprogrammatic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-30
Application #
8038237
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
30
Fiscal Year
2010
Total Cost
$24,559
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Saint Fleur-Lominy, Shella; Maus, Mate; Vaeth, Martin et al. (2018) STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Rep 24:3045-3060.e5
Puranik, Amrutesh S; Leaf, Irina A; Jensen, Mark A et al. (2018) Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Sci Rep 8:13948
Weng, Mao-Wen; Lee, Hyun-Wook; Park, Sung-Hyun et al. (2018) Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis. Proc Natl Acad Sci U S A 115:E6152-E6161
Cui, Xin; Morales, Renee-Tyler Tan; Qian, Weiyi et al. (2018) Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis. Biomaterials 161:164-178
Burgess, Hannah M; Pourchet, Aldo; Hajdu, Cristina H et al. (2018) Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus. Mol Ther Oncolytics 8:71-81
Wong, Serre-Yu; Coffre, Maryaline; Ramanan, Deepshika et al. (2018) B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. J Immunol 201:1442-1451
Handler, Jesse; Cullis, Jane; Avanzi, Antonina et al. (2018) Pre-neoplastic pancreas cells enter a partially mesenchymal state following transient TGF-? exposure. Oncogene 37:4334-4342
Diamond, Julie M; Vanpouille-Box, Claire; Spada, Sheila et al. (2018) Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. Cancer Immunol Res 6:910-920
Fan, Xiaozhou; Peters, Brandilyn A; Jacobs, Eric J et al. (2018) Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults. Microbiome 6:59
Chen, Danqi; Fang, Lei; Mei, Shenglin et al. (2018) Erratum: ""Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells"". Environ Health Perspect 126:019001

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