Abstract

The overarching goal of the BioRepository Center (BRC) is to facilitate translational research. Tight coordination between surgical staff, pathologists, and BRC enables collection of specimens to fulfill investigators'needs. Our protocols for rapid acquisition of tissue samples allows for preparation of high quality analytes. Patients'rights and privacy by our participation in obtaining and confirming informed consent for tissue collection;guidance with regard to preparation and submission of IRB documents is offered to help ensure compliance. The BRC also promotes collaborations between clinical and basic scientists, and can aid in the design and execution of prospective, hypothesis-driven studies to examine the impact of genetics or treatment on disease progression. By promoting investigators access to appropriate biospecimens, the BRC enhances the ability of NYULMC Cancer Institute members to perform meaningful translational research.

Public Health Relevance

The BioRepository Center (BRC) plays a critical role in promoting translational research at NYU Cancer Institute (NYUCI). By coordinating with surgeons and other clinicians, we help scientists obtain human tissues that they need. This allows for investigations of pathologic processes or novel therapeutics, with the most relevance to human disease, and linking and expanding findings initially discovered in model systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016087-33
Application #
8436441
Study Section
Subcommittee G - Education (NCI)
Project Start
2013-03-01
Project End
2018-02-28
Budget Start
2013-04-01
Budget End
2014-02-28
Support Year
33
Fiscal Year
2013
Total Cost
$137,380
Indirect Cost
$56,330

  Institution

Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

de la Parra, Columba; Ernlund, Amanda; Alard, Amandine et al. (2018) A widespread alternate form of cap-dependent mRNA translation initiation. Nat Commun 9:3068
Coux, Rémi-Xavier; Teixeira, Felipe Karam; Lehmann, Ruth (2018) L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary. Development 145:
Patibandla, Jay R; Fehniger, Julia E; Levine, Douglas A et al. (2018) Small cell cancers of the female genital tract: Molecular and clinical aspects. Gynecol Oncol 149:420-427
Fanok, Melania H; Sun, Amy; Fogli, Laura K et al. (2018) Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma. J Invest Dermatol 138:1116-1125
Berger, Ashton C; Korkut, Anil; Kanchi, Rupa S et al. (2018) A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. Cancer Cell 33:690-705.e9
Harper, Lamia; Balasubramanian, Divya; Ohneck, Elizabeth A et al. (2018) Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence. MBio 9:
Llewellyn, Sean R; Britton, Graham J; Contijoch, Eduardo J et al. (2018) Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice. Gastroenterology 154:1037-1046.e2
Gowen, Michael F; Giles, Keith M; Simpson, Danny et al. (2018) Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors. J Transl Med 16:82
Chiou, Kenneth L; Bergey, Christina M (2018) Methylation-based enrichment facilitates low-cost, noninvasive genomic scale sequencing of populations from feces. Sci Rep 8:1975
Pelzek, Adam J; Shopsin, Bo; Radke, Emily E et al. (2018) Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection. MBio 9:

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