Center for Biospecimen Research & Development (CBRD) The Center for Biospecimen Research and Development (CBRD) was launched in 2015 and has replaced the BioRepository Center (BRC) shared resource presented at the last CCSG review on 2012. Under the direction of Andre Moreira, MD, PhD, Director of Surgical Pathology at NYU Langone Health (NYULH) and a recognized expert in lung pathology and biospecimen research, CBRD was created to support the increased demand across the NYULH research enterprise for standardized human biospecimens. CBRD focuses on improving the accessibility of human biospecimen resources to investigators and increasing institution-wide banking efforts and capacity. CBRD has implemented a campus-wide universal consent and policy for human biospecimen collection and storage to ensure regulatory compliance. CBRD provides well- annotated, high quality biospecimens that foster impactful translational research, thus guaranteeing the clinical relevance of basic findings. CBRD also supports the rapidly expanding portfolio of Perlmutter Cancer Center (PCC) investigator initiated clinical trials by facilitating acquisition, processing and distribution of biospecimens from enrolled patients. All of the samples collected are linked to clinical information obtained in our electronic medical record, EPIC.
The Specific Aims of CBRD are:
Aim 1) To maintain and expand a prospective Biospecimen Repository of PCC patient samples, as well as maintain and expand its linked clinicopathological information;
Aim 2) To process biospecimens, including by carrying out nucleic acid extraction and provide specialized Pathology support;
Aim 3) To stimulate collaborations involving the distribution of human biospecimens;
and Aim 4) To apply high quality control that meets national and international standards, as well as governance over biospecimen utilization.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016087-40
Application #
10124311
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-12-01
Project End
2024-02-29
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
40
Fiscal Year
2021
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Saint Fleur-Lominy, Shella; Maus, Mate; Vaeth, Martin et al. (2018) STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia. Cell Rep 24:3045-3060.e5
Puranik, Amrutesh S; Leaf, Irina A; Jensen, Mark A et al. (2018) Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Sci Rep 8:13948
Weng, Mao-Wen; Lee, Hyun-Wook; Park, Sung-Hyun et al. (2018) Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis. Proc Natl Acad Sci U S A 115:E6152-E6161
Cui, Xin; Morales, Renee-Tyler Tan; Qian, Weiyi et al. (2018) Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis. Biomaterials 161:164-178
Burgess, Hannah M; Pourchet, Aldo; Hajdu, Cristina H et al. (2018) Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus. Mol Ther Oncolytics 8:71-81
Wong, Serre-Yu; Coffre, Maryaline; Ramanan, Deepshika et al. (2018) B Cell Defects Observed in Nod2 Knockout Mice Are a Consequence of a Dock2 Mutation Frequently Found in Inbred Strains. J Immunol 201:1442-1451
Handler, Jesse; Cullis, Jane; Avanzi, Antonina et al. (2018) Pre-neoplastic pancreas cells enter a partially mesenchymal state following transient TGF-? exposure. Oncogene 37:4334-4342
Diamond, Julie M; Vanpouille-Box, Claire; Spada, Sheila et al. (2018) Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. Cancer Immunol Res 6:910-920
Fan, Xiaozhou; Peters, Brandilyn A; Jacobs, Eric J et al. (2018) Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults. Microbiome 6:59
Chen, Danqi; Fang, Lei; Mei, Shenglin et al. (2018) Erratum: ""Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells"". Environ Health Perspect 126:019001

Showing the most recent 10 out of 1170 publications