Abstract

RADIOBIOLOGYANDRADIOTHERAPYRESEARCHPROGRAM PROGRAMCODE:RR PROGRAMSUMMARY/ABSTRACT TheRadiobiology&Radiotherapy(RR)ResearchProgramcomprisesabroadlybased,multifacetedresearch effortinradiationtherapy,radiationbiology,radiologicalphysics,andrelatedareasoftumorbiology,including amajoreffortinDNAdamageandrepair.Itslong-termgoalistoimprovethetreatmentofcanceringeneral andtheeffectivenessofradiationtherapyinparticular.
The SpecificAims oftheprogramaretoelucidate pathwaysofcancerbiologythatimpactradiationtherapyandtoconductclinicalandtranslationalresearch aimedatimprovingradiationtherapy.Theprogramincludesabroadspectrumofactivitythatextendsfrom laboratory-basedexperimentalresearchtoclinicalinvestigation,anditfeatures36investigatorswithinten departments.Keythemesincludestudiesof:1)carcinogenesis,geneticinstability,andcellgrowthcontrol;?2) elucidationofDNArepairpathways,andinvestigationoftumorhypoxiaandtheimpactofhypoxiaoncancer therapy;?3)preclinicaldevelopmentofradiationsensitizersandDNArepairinhibitors,includingcombinationof DNArepairinhibitorswithimmunetherapy;?4)molecularcorrelationswithoutcomesinradiationtherapy;?5) healthservicesanddisparitiesresearchinradiationoncology;?6)designandconductofclinicaltrialsrelevant toradiationoncology;?and7)improvementsinradiationdosimetry,imaging,anddelivery.Mostprogram memberscollaborateactivelywithinvestigatorsinotherYCCprograms,and34%ofthe555RRpublicationsin thepastfundingperiodrepresentinter-programmaticcollaborations.Thesecollaborativeinteractionsstimulate translationalresearchthatisfacilitatedbyextensiveuseofsharedresources.Thenumerouscancer-related grandrounds,seminars,meetings,andjournalclubssponsoredbyYCC,alongwiththeweeklyRadiobiology WorkshopandTherapeuticRadiologyGrandRoundssponsoredbytheprogram,encouragecooperation, mutualsupport,andcross-stimulationamongresearchteams,whichleadstomorerapidandefficient applicationofresearchresultstoclinicalpractice.TheprogramleadersareDr.PeterM.GlazerandDr.Joann Sweasy.Dr.Glazertookoverasleaderin2002,replacingDr.JamesJ.Fischer,whohadservedasprogram leadersinceitsinception.Inthepastfundingperiod,Dr.JoannSweasywasnamedco-leader.TogetherDrs. GlazerandSweasyhaverecruitedseveralbasicscientistsandphysicianinvestigatorstotheCancerCenter. Theprogramalsohascompletedrenovationof15,500ft2 oflaboratoryspace,partiallyfundedbya$2million constructiongrantfromtheNIH.Dr.Glazeralsoservesasco-PI(withDavidStern,ST)ofaT32pre-and postdoctoraltraininggrantincancerbiology,whichincludesfacultydrawnfromRR,ST,andotherYCC programs.AsofJune1,2017,the36programinvestigatorshavepeer-reviewedfundingof$5.7Minannual directcosts,including18R01s.Ofthisfunding,$3.6M(annualdirectcosts)comesfromtheNCI,including12 R01sandtwoR21s.Thisrepresentsa55%increaseinpeer-reviewedcancerfundinganda138% increaseinNCIfundingsincethelastrenewal.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016359-41
Application #
9989600
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
41
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Bonazzoli, Elena; Predolini, Federica; Cocco, Emiliano et al. (2018) Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer. Clin Cancer Res 24:4845-4853
Villarroel-Espindola, Franz; Yu, Xiaoqing; Datar, Ila et al. (2018) Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non-Small Cell Lung Cancer. Clin Cancer Res 24:1562-1573
Wadia, Roxanne J; Stolar, Marilyn; Grens, Clarice et al. (2018) The prevention of chemotherapy induced peripheral neuropathy by concurrent treatment with drugs used for bipolar disease: a retrospective chart analysis in human cancer patients. Oncotarget 9:7322-7331
De Feyter, Henk M; Behar, Kevin L; Corbin, Zachary A et al. (2018) Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv 4:eaat7314
Ventura, Alessandra; Vassall, Aaron; Robinson, Eve et al. (2018) Extracorporeal Photochemotherapy Drives Monocyte-to-Dendritic Cell Maturation to Induce Anticancer Immunity. Cancer Res 78:4045-4058
Xiao, Qian; Wu, Jibo; Wang, Wei-Jia et al. (2018) DKK2 imparts tumor immunity evasion through ?-catenin-independent suppression of cytotoxic immune-cell activation. Nat Med 24:262-270
Jagannath, Sundar; Laubach, Jacob; Wong, Ellice et al. (2018) Elotuzumab monotherapy in patients with smouldering multiple myeloma: a phase 2 study. Br J Haematol 182:495-503
Liu, Xiaoni; Zhang, Shang-Min; McGeary, Meaghan K et al. (2018) KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations. Mol Cancer Ther :
Chae, Wook-Jin; Bothwell, Alfred L M (2018) Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside. Front Immunol 9:303
Kim, Hanseul; Keum, NaNa; Giovannucci, Edward L et al. (2018) Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer 143:1047-1053

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