Cancer Center Support Grant

Glick, John H.

Abstract

The University of Pennsylvania Cancer Center (UPCC) is a multidisciplinary program in cancer research, education, clinical care, and community service. It is one component of the Fox Chase/University of Pennsylvania Comprehensive Cancer Center. Based inthe School of Medicine, the UPCC involves faculty from many schools of the University. It includes four major research divisions, each with distinct research programs: Clinical Research, Fundamental Research, Human REsources Research, and Epidemiology/Biostatistics Research. Shared Resources serve these various programs. Clinical Research encompasses a broad Clinical Trials Program and specific programmatic efforts in Nutrition and in Melanoma. Fundamental Research includes Immunobiology, Hematopoietic Cell Biology, and Molecular Genetics. Human Resources Research includes the Psychosocial and Palliative Care Research Programs and research in Health Care Economics. Epidemiology and Biostatistics encompasses Epidemiology Research, Biostatistics Research, the Center's patienbt data base and a Biostatistics Consulting Unit, one of nine Shared Resources within the UPCC. Other Shared Resources are the Clinical Trials Data Center, the Oncology Study (Inpatient) Unit, the Nutrition Core, the Pharmacology Core Laboratory, the Cell (Tissue Culture) Center, the Fluorescence Division of Human Resources Research. Interdisciplinary cancer education programs fostered by the Center supplement departmental efforts in cancer education. Extension of the Center's research and education programs into the the community serve the goals of cancer control. The Center's developmental efforts are directed toward expanding Epidemiology; continuing the growth of Molecular Genetics; building research related to Membrane Receptors; bridging the clinical and fundamental research programs related to Human Leukemia; and extending psychosocial research to include Biologic Studies relevant to human behavior. This application requests core support for the Center's research programs.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA016520-14
• Application #: 3101589
• Study Section: Cancer Center Support Grant Review Committee (CCS)
• Project Start: 1978-12-01
• Project End: 1989-11-30
• Budget Start: 1988-12-01
• Budget End: 1989-11-30
• Support Year: 14
• Fiscal Year: 1989

Institution

• Name: University of Pennsylvania
• Type: Schools of Medicine
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104

Publications

Raposo-Ferreira, Talita M M; Brisson, Becky K; Durham, Amy C et al. (2018) Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Vet Pathol 55:622-633

Kasner, Margaret T; Mick, Rosemarie; Jeschke, Grace R et al. (2018) Sirolimus enhances remission induction in patients with high risk acute myeloid leukemia and mTORC1 target inhibition. Invest New Drugs 36:657-666

Karakasheva, Tatiana A; Lin, Eric W; Tang, Qiaosi et al. (2018) IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. Cancer Res 78:4957-4970

Huffman, Austin P; Richman, Lee P; Crisalli, Lisa et al. (2018) Pharmacodynamic Monitoring Predicts Outcomes of CCR5 Blockade as Graft-versus-Host Disease Prophylaxis. Biol Blood Marrow Transplant 24:594-599

Yam, Clinton; Xu, Xiaowei; Davies, Michael A et al. (2018) A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600-Mutant Solid Tumors. Clin Cancer Res 24:22-32

Huang, Mo; Wang, Jingshu; Torre, Eduardo et al. (2018) SAVER: gene expression recovery for single-cell RNA sequencing. Nat Methods 15:539-542

Rebecca, Vito W; Nicastri, Michael C; Fennelly, Colin et al. (2018) PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer. Cancer Discov :

Onorati, Angelique V; Dyczynski, Matheus; Ojha, Rani et al. (2018) Targeting autophagy in cancer. Cancer 124:3307-3318

Jang, Jeong Hoon; Manatunga, Amita K; Taylor, Andrew T et al. (2018) Overall indices for assessing agreement among multiple raters. Stat Med 37:4200-4215

Garfall, Alfred L; Stadtmauer, Edward A; Hwang, Wei-Ting et al. (2018) Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI Insight 3: