Abstract

The proposal has significance in that it would establish the scientific capability, the administrative expertise and essential physical equipment for: 1. On-going pharmacologic study of established, effective oncologic drugs used in treating malignancies of childhood permitting: a. Rational rather than empirical dosage schedules, b. better understanding of toxicity and its prevention, c. comparison of pharmacokinetics in children with published data for adults with a view to determining age related differences, and d. monitoring for compliance to permit better evaluation of individuals, as well as groups of patients, to give the physician an opportunity to secure better compliance should it be lacking. 2. Pharmacologic evaluation of new formulations of drugs used in treating cancer in children. The actual research projected centers around the expertise of Dr. Nelson in applying methodology of cancer drugs to research and cancer problems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016672-16
Application #
3101602
Study Section
Special Emphasis Panel (SRC (15))
Project Start
1978-07-01
Project End
1992-06-30
Budget Start
1990-07-23
Budget End
1991-06-30
Support Year
16
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Boddu, Prajwal; Masarova, Lucia; Verstovsek, Srdan et al. (2018) Patient characteristics and outcomes in adolescents and young adults with classical Philadelphia chromosome-negative myeloproliferative neoplasms. Ann Hematol 97:109-121
Casasent, Anna K; Schalck, Aislyn; Gao, Ruli et al. (2018) Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing. Cell 172:205-217.e12
Noh, Hyangsoon; Zhao, Qingnan; Yan, Jun et al. (2018) Cell surface vimentin-targeted monoclonal antibody 86C increases sensitivity to temozolomide in glioma stem cells. Cancer Lett 433:176-185
Hutcheson, Katherine A; Barrow, Martha P; Plowman, Emily K et al. (2018) Expiratory muscle strength training for radiation-associated aspiration after head and neck cancer: A case series. Laryngoscope 128:1044-1051
Zhao, Jun; Xiao, Zhilan; Li, Tingting et al. (2018) Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer. ACS Nano 12:9881-9893
Akhtari, Mani; Milgrom, Sarah A; Pinnix, Chelsea C et al. (2018) Reclassifying patients with early-stage Hodgkin lymphoma based on functional radiographic markers at presentation. Blood 131:84-94
Barua, Souptik; Solis, Luisa; Parra, Edwin Roger et al. (2018) A Functional Spatial Analysis Platform for Discovery of Immunological Interactions Predictive of Low-Grade to High-Grade Transition of Pancreatic Intraductal Papillary Mucinous Neoplasms. Cancer Inform 17:1176935118782880
Ma, Junsheng; Chan, Wenyaw; Tilley, Barbara C (2018) Continuous time Markov chain approaches for analyzing transtheoretical models of health behavioral change: A case study and comparison of model estimations. Stat Methods Med Res 27:593-607
Bayraktar, Recep; Ivan, Cristina; Bayraktar, Emine et al. (2018) Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion. Clin Cancer Res 24:4225-4241
Parra, Edwin R; Villalobos, Pamela; Mino, Barbara et al. (2018) Comparison of Different Antibody Clones for Immunohistochemistry Detection of Programmed Cell Death Ligand 1 (PD-L1) on Non-Small Cell Lung Carcinoma. Appl Immunohistochem Mol Morphol 26:83-93

Showing the most recent 10 out of 12418 publications