A continuing need for biostatistical collaboration throughout the institution and in all stages of clinical and translational research, including planning, design, conduct and data management, intermit and final analysis and reporting. The Biostatistical Resource Group (BRG) provides this consultation and collaboration for clinical investigators and basic scientists who hold National Cancer Institute funded grants or support from other approved peer-reviewed funding agencies. The staff from the BRG, in conjunction with the Clinical Trials Support Resource, participate in the review of a large number of clinical protocols that are developed at the M.D. Anderson Cancer Center or through cooperative groups and pharmaceutical corporation collaboration. From January 1, 1996 through December 31, 1996, 225 protocols were reviewed including 36 Phase I, 71 Phase II, 25 Phase III, 1 Phase IV, 12 Pilot, and 80 other studies. This number is expected to increase by 10 to 15% yearly. The Biostatistical Resource Group provides training in the area of biostatistical principles and methods for the design and analysis of studies. In conjunction with staff from the Division of Medicine, statistical and design issue pertinent to Phase I-III clinical trials have been incorporated into the training program. The BRG also develops a modest amount of biostatistical software for the design, monitoring and analysis of trials in which they are involved. The Biostatistics Resource Group is housed within the Department of Biomathematics in the Houston Main Building. In this environment, they are supported by the latest workstations, servers, and laser printers and the modern statistical and database management software packages.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA016672-25S1
Application #
6347268
Study Section
Project Start
2000-08-30
Project End
2001-06-30
Budget Start
Budget End
Support Year
25
Fiscal Year
2000
Total Cost
$254,104
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Wang, Jue; Zhao, Wei; Guo, Huifang et al. (2018) AKT isoform-specific expression and activation across cancer lineages. BMC Cancer 18:742
Lu, Zhongming; Sturgis, Erich M; Zhu, Lijun et al. (2018) Mouse double minute 4 variants modify susceptibility to risk of recurrence in patients with squamous cell carcinoma of the oropharynx. Mol Carcinog 57:361-369
Murray, Thomas A; Yuan, Ying; Thall, Peter F et al. (2018) A utility-based design for randomized comparative trials with ordinal outcomes and prognostic subgroups. Biometrics 74:1095-1103
Sun, Lin-Lin; Yang, Ri-Yao; Li, Chia-Wei et al. (2018) Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing. Am J Cancer Res 8:1307-1316
Yam, Clinton; Xu, Xiaowei; Davies, Michael A et al. (2018) A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600-Mutant Solid Tumors. Clin Cancer Res 24:22-32
Veletic, Ivo; Manshouri, Taghi; Newberry, Kate J et al. (2018) Pentraxin-3 plasma levels correlate with tumour burden and overall survival in patients with primary myelofibrosis. Br J Haematol :
El Fakih, Riad; Jabbour, Elias; Ravandi, Farhad et al. (2018) Current paradigms in the management of Philadelphia chromosome positive acute lymphoblastic leukemia in adults. Am J Hematol 93:286-295
Sankhala, Kamalesh; Takimoto, Chris H; Mita, Alain C et al. (2018) Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules. Invest New Drugs :
Shen, Weining; Ning, Jing; Yuan, Ying et al. (2018) Model-free scoring system for risk prediction with application to hepatocellular carcinoma study. Biometrics 74:239-248
Wu, Shaofang; Wang, Shuzhen; Gao, Feng et al. (2018) Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma. Neuro Oncol 20:78-91

Showing the most recent 10 out of 12418 publications