The Tissue Procurement and Banking Facility (TPBF) provides all basic science and clinical investigators atMDACC with access to human tissues that have been removed by therapeutic resection or biopsy. Thegoals of the shared resource are to: 1) maintain a flexible specialized tissue-procurement resource thatprovides requesting investigators efficient and expeditious delivery to requesting investigators of freshlyobtainedwell-characterized and custom-processed tumor and control tissue from patients in operatingrooms, procedure rooms and clinics; 2) maintain and improve a centralized institution-wide tissueprocurement and banking core facility that provides specimens according to NCI Best Practices forBiospecimen Resources and compatible with current, emerging, and anticipated methodologies for analysisof DNA, RNA and protein; 3) interface with other institutional databases to enhance the intranet-baseddatabase so it will provide epidemiology, family history, patient treatment, and patient outcome; 4) supportthe individual programmatically administered and funded satellite tissue banks operational within theinstitution, including those maintained by disease sites, SPOREs and P01s; and 5) meet the federal, stateand institutional regulatory requirements for use of human tissue in research and protection of humansubjects. The Facility occupies 379 sq ft and 187 sq ft within the two Surgical Pathology suites and has aseparate 2,500 sq ft secure, monitored, environmentally-controlled facility with 21 freezers. Additional tissueprocessing rooms for TPBF use are located in each clinic with procedure rooms. The TPBF is staffed with aDirector, Laboratory Manager, 2 Tissue Procurement Specialists, 2 Tissue Laboratory Assistants, a DataCoordinator, and a Clinical Research Coordinator. During the previous funding period, 154,122 specimenswere collected from 21,902 cases. A total of 124,378 specimens were distributed with 87% provided to 14peer-reviewed funded satellite banks, 5% to peer-reviewed funded individual investigators, 7% to non-peerreviewed funded individual investigators, and 1% to non-peer reviewed funded satellite banks. Individualinvestigators can obtain tissue specimens from satellite banks and the TPBF. TPBF services were used by66 investigators from 19 of the 21 CCSG programs. 65% of the individual users had peer-reviewed fundingand accounted for 40% of the utilization by individual users. Future plans are focused on interfacing withclinical, epidemiologic, tumor registry, and protocol databases to enhance specimen annotation through theTissueStation and ResearchStation software initiatives; quality control/quality assurance including evaluationwith the Biospecimen Repository Evaluation Tool (BRET) from the National Cancer Institute; completion ofcompliance with the NCI Best Practices for Biospecimen Resources that were issued in June of 2007 andClinical Laboratory Improvement Act of 1988, and continuing to expand capacity to meet research needs.
Showing the most recent 10 out of 12418 publications
