Abstract

The objectives of this program are to provide for basic and clinical research opportunities and education in the problems of childhood cancer, particularly in terms of gaining new insights into the fundamental aspects of the biology of cancer and its treatment. Currently, this program has provided care for over 5,000 children with cancer. Treatment programs are conducted according to research protocols in order to provide opportunities for continuous improvement of treatment regimens and also to provide necessary data acquisition for development of new knowledge concerning clinical aspects of childhood cancer. In addition, there are five departments of basic laboratory research: Virology/Molecular Biology, Biochemistry, Biochemical and Clinical Pharmacology, Immunology, and Tumor Cell Biology. Many opportunities are being realized for coordinative research involving both clinical and basic cancer center investigators. CORE grant support permits the accomplishments of these objectives within the unique capabilities of St. Jude Children's Research Hospital, the only NCI-sponsored cancer center devoted solely to cancer in children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA021765-14
Application #
3101654
Study Section
Special Emphasis Panel (SRC (15))
Project Start
1977-09-01
Project End
1992-02-29
Budget Start
1991-03-13
Budget End
1992-02-29
Support Year
14
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Nishii, Rina; Moriyama, Takaya; Janke, Laura J et al. (2018) Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy. Blood 131:2466-2474
Fernandez-Pineda, Israel; Davidoff, Andrew M; Lu, Lu et al. (2018) Impact of ovarian transposition before pelvic irradiation on ovarian function among long-term survivors of childhood Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study. Pediatr Blood Cancer 65:e27232
Stewart, Elizabeth; McEvoy, Justina; Wang, Hong et al. (2018) Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell 34:411-426.e19
Broniscer, Alberto; Hwang, Scott N; Chamdine, Omar et al. (2018) Bithalamic gliomas may be molecularly distinct from their unilateral high-grade counterparts. Brain Pathol 28:112-120
Wogksch, Matthew D; Howell, Carrie R; Wilson, Carmen L et al. (2018) Physical fitness in survivors of childhood Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort. Pediatr Blood Cancer :e27506
Halalsheh, Hadeel; Kaste, Sue C; Navid, Fariba et al. (2018) The role of routine imaging in pediatric cutaneous melanoma. Pediatr Blood Cancer 65:e27412
Wang, Lu; Hiler, Daniel; Xu, Beisi et al. (2018) Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures. Cell Rep 22:2601-2614
Vanarotti, Murugendra; Evison, Benjamin J; Actis, Marcelo L et al. (2018) Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance. Bioorg Med Chem 26:2345-2353
Quinn, Melissa; Fannin, J T; Sciasci, Joseph et al. (2018) Pentamidine for Prophylaxis against Pneumocystis jirovecii Pneumonia in Pediatric Oncology Patients Receiving Immunosuppressive Chemotherapy. Antimicrob Agents Chemother 62:
Brinkman, Tara M; Recklitis, Christopher J; Michel, Gisela et al. (2018) Psychological Symptoms, Social Outcomes, Socioeconomic Attainment, and Health Behaviors Among Survivors of Childhood Cancer: Current State of the Literature. J Clin Oncol 36:2190-2197

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