The Comprehensive Cancer Center of Metropolitan Detroit (CCCMD) received its initial core funding and designation by the Director of the National Cancer Institue in 1978. The CCCMD was established through the affiliation of the Michigan Cancer Foundation and the Wayne State University School of Medicine, for the propose of facilitating interdisciplinary and interdepartmental activities in cancer research and cancer care, to coordinate and integrate the cancer-related activities in its metropolitan region, and of supporting the augmentation of cancer resources in this area. Since formation of the CCCMD, emphasis has been placed on the initiation and support of multidisciplanary, interinstitutional, and broad-based projects and programs. The CCCMD core grant has provided the opportunity for the orderly acquisition of cancer research and resource facilities; superior staff development; establishment and sustenance of interinstitutional and interdepartmental cancer research collaborations; and overall enhancement of cancer research and care achievements in Detroit. The task of coordinating the collaborative and multi-interest programs described in this application falls to the leadership of the Center, the Director, the Associate Directors, and their staffs. Each Associate Director is responsible for the planning and initiation of broad-based programs; and the Center's Operating Committee, which includes the Center Director, is responsible for overall program planning, cross-disciplinary collaborations, and the identification of worthwhile development projects in all program areas. Renewal of this core grant is requested to sustain the work of the CCCMD.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA022453-13
Application #
3101677
Study Section
Special Emphasis Panel (SRC (15))
Project Start
1988-04-01
Project End
1992-03-31
Budget Start
1990-07-01
Budget End
1991-03-31
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Su, Yongwei; Li, Xinyu; Ma, Jun et al. (2018) Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo. Biochem Pharmacol 148:13-26
Bonomi, Robin; Popov, Vadim; Laws, Maxwell T et al. (2018) Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide. J Med Chem 61:7116-7130
Paximadis, Peter; Beebe-Dimmer, Jennifer L; George, Julie et al. (2018) Comparing Treatment Strategies for Stage I Small-cell lung Cancer. Clin Lung Cancer 19:e559-e565
Modi, Dipenkumar; Al-Kadhimi, Zaid; Chen, Wei et al. (2018) A phase II study of tacrolimus and thymoglobulin as graft-versus-host-disease prophylaxis in related donor allogeneic hematopoietic cell transplantation. Am J Hematol 93:E96-E98
Patki, Mugdha; McFall, Thomas; Rosati, Rayna et al. (2018) Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Sci Rep 8:16006
Teslow, Emily A; Bao, Bin; Dyson, Greg et al. (2018) Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells. Mol Oncol 12:1138-1152
Rathinam, Rajamani; Rosati, Rita; Jamesdaniel, Samson (2018) CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth. J Cell Biochem 119:3545-3553
Munkanatta Godage, Dhanushka N P; VanHecke, Garrett C; Samarasinghe, Kusal T G et al. (2018) SMYD2 glutathionylation contributes to degradation of sarcomeric proteins. Nat Commun 9:4341
Han, Jing; Li, Yue; Liu, Xiuli et al. (2018) Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo. PLoS One 13:e0193031
Kim, Seongho; Wong, Weng Kee (2018) Discussion on Optimal treatment allocations in space and time for on-line control of an emerging infectious disease. J R Stat Soc Ser C Appl Stat 67:778-779

Showing the most recent 10 out of 826 publications