SHARED RESOURCE MANAGEMENT ? ABSTRACT Shared Resources are organized and maintained to meet the scientific needs of the members of Karmanos Cancer Institute (KCI). KCI operates eight center-managed Shared Resources as follows; Animal Model and Therapeutics Evaluation Core (AMTEC), Biobanking and Correlative Sciences (BCS) Core, Behavioral and Field Research Core (BFRC), Biostatistics and Bioinformatics Core (BBC), Epidemiology Research Core (ERC), Microscopy, Imaging, and Cytometry Resources (MICR) Core, Pharmacology and Metabolomics Core (PMC), and a Proteomics Core. Together, these Shared Resources provide access to specialized technologies, services, and expertise that enhance scientific interaction and productivity at the Cancer Center. Of the 1,775 peer-reviewed articles published by cancer center members during the current reporting period (12/1/2015 ? 11/30/2019), 561 (31.6%) articles utilized the services of at least one KCI Shared Resource. KCI Shared Resources are managed within the planning and evaluation structure of the Cancer Center including senior leadership oversight of the scientific and strategic progress, reporting and business management provided by Administration, and regular user feedback provided through survey tools and Core Advisory Committees. Future plans are proposed to address the needs of the membership and the scientific progress of the Cancer Center. Additionally, a developing Cyclotron-Radiochemistry Core will provide various radiotracers for pre- clinical and clinical research conducted by the Cancer Center membership on a fee-for-service basis. CCSG funding for Cores was augmented by institutional support in excess of $6.0 million directed to ensure success of Shared Resources.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA022453-39
Application #
10088982
Study Section
Special Emphasis Panel (ZCA1)
Project Start
1997-08-08
Project End
2025-11-30
Budget Start
2020-12-15
Budget End
2021-11-30
Support Year
39
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
McKnight, Brooke N; Viola-Villegas, Nerissa T (2018) Monitoring Src status after dasatinib treatment in HER2+ breast cancer with 89Zr-trastuzumab PET imaging. Breast Cancer Res 20:130
McFall, Thomas; McKnight, Brooke; Rosati, Rayna et al. (2018) Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen. J Biol Chem 293:1163-1177
Dyson, Greg; Farran, Batoul; Bolton, Susan et al. (2018) The extrema of circulating miR-17 are identified as biomarkers for aggressive prostate cancer. Am J Cancer Res 8:2088-2095
Greenwald, Mark K; Ruterbusch, Julie J; Beebe-Dimmer, Jennifer L et al. (2018) Risk of incident claims for chemotherapy-induced peripheral neuropathy among women with breast cancer in a Medicare population. Cancer :
An, Mingrui; Wu, Jing; Zhu, Jianhui et al. (2018) Comparison of an Optimized Ultracentrifugation Method versus Size-Exclusion Chromatography for Isolation of Exosomes from Human Serum. J Proteome Res 17:3599-3605
Shah, Seema; Brock, Ethan J; Jackson, Ryan M et al. (2018) Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation. Neoplasia 20:951-963
Kariburyo, Furaha; Wang, Yuexi; Cheng, I-Ning Elaine et al. (2018) Observation versus treatment among men with favorable risk prostate cancer in a community-based integrated health care system: a retrospective cohort study. BMC Urol 18:55
Yu, Chunsong; An, Myunggi; Jones, Evan et al. (2018) Targeting Suppressive Oligonucleotide to Lymph Nodes Inhibits Toll-like Receptor-9-Mediated Activation of Adaptive Immunity. Pharm Res 35:56
Thakur, Manish K; Heilbrun, Lance; Dobson, Kimberlee et al. (2018) Phase I Trial of the Combination of Docetaxel, Prednisone, and Pasireotide in Metastatic Castrate-Resistant Prostate Cancer. Clin Genitourin Cancer 16:e695-e703
Feldmann, Daniel P; Cheng, Yilong; Kandil, Rima et al. (2018) In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. J Control Release 276:50-58

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