Abstract

The mission of the Arizona Cancer Center (AZCC) is to prevent and cure cancer. To continue that mission, this application requests a 5-year renewal of the Cancer Center Support Grant (CCSG). The AZCC was founded as a Division of the College of Medicine (COM), University of Arizona (UA) in 1976. It obtained a CCSG in 1978 and was designated a Comprehensive Cancer Center by the NCI in 1990. To accomplish our mission, the basic and translational/clinical and cancer prevention and control research is carried out in six programs, including molecular genetics, cancer metastases and signaling, cancer imaging and technology, gastrointestinal cancer, therapeutic development and cancer prevention and control. These programs are supported by 20 shared services, which help the AZCC (the whole) be greater than the sum of the parts. Since the last renewal, the AZCC team has substantially increased their peer reviewed funding and garnered additional program projects and a GI cancer SPORE. Those accomplishments demonstrate the interdisciplinary activities of the Cancer Center. As we hope the reviewers will see, the team has made considerable progress in their basic and clinical science, including bringing two therapeutic and five prevention agents forward into clinical trials. The renewal outlined in this application is critical to keep us working to accomplish our mission.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA023074-30S4
Application #
7498596
Study Section
Subcommittee G - Education (NCI)
Program Officer
Silkensen, Shannon M
Project Start
1978-09-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2009-06-30
Support Year
30
Fiscal Year
2007
Total Cost
$88,172
Indirect Cost

  Institution

Name
University of Arizona
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

McLamarrah, Tiffany A; Buster, Daniel W; Galletta, Brian J et al. (2018) An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly. J Cell Biol 217:1217-1231
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Glassman, Caleb R; Parrish, Heather L; Lee, Mark S et al. (2018) Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep 22:1263-1275
Nair, Uma S; Brady, Benjamin R; O'Connor, Patrick A et al. (2018) Factors Predicting Client Re-Enrollment in Tobacco Cessation Services in a State Quitline. Prev Chronic Dis 15:E126
Akam, E A; Utterback, R D; Marcero, J R et al. (2018) Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production. J Inorg Biochem 180:186-193
Hadinger, Kyle P; Marshalek, Joseph P; Sheeran, Paul S et al. (2018) Optimization of Phase-Change Contrast Agents for Targeting MDA-MB-231 Breast Cancer Cells. Ultrasound Med Biol 44:2728-2738
Han, Jiali; Li, Jianrong; Achour, Ikbel et al. (2018) Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements. Pac Symp Biocomput 23:524-535
Galbraith, David W; Sliwinska, Elwira; Samadder, Partha (2018) Nuclear Cytometry: Analysis of the Patterns of DNA Synthesis and Transcription Using Flow Cytometry, Confocal Microscopy, and RNA Sequencing. Methods Mol Biol 1678:371-392
Nguyen, Mike M; Martinez, Jessica A; Hsu, Chiu-Hsieh et al. (2018) Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. Eur J Cancer Prev 27:557-562
Zeltzer, Sebastian; Zeltzer, Carol A; Igarashi, Suzu et al. (2018) Virus Control of Trafficking from Sorting Endosomes. MBio 9:

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