The purview of basic cancer research is to address the fundamental mechanisms of biological processes that underlie the initiation and the progression of cancer. Over the past 2 decades, studies of cancer biology have led to the establishment of a general framework for tumor development. In this framework, a series of 8 biological events required for the formation of cancer have been identified: (a) increased cell proliferation, (b) decreased cell death, (c) defects in terminal differentiation, (d) escape from life-span restriction, (e) genome instability, (f) immune evasion, (g) angiogenesis, and (h) invasion and metastasis. Members of the Cancer Biology and Signaling (CBS) Program conduct basic research on the biological processes that underlie the initiation and progression of cancer. The scientific goals of the CBS Program are to fill some of those gaps in knowledge, focusing on fundamental mechanisms in 2 general areas of biology: signal transduction and cell growth. The CBS program has 34 members from 8 academic departments with $14.3 Million of peer-reviewed research grant funding (annual direct costs), including $3.4 Million from NCI. Members of the CBS Program published 751 programmatically aligned articles (2007-2012);10% were the result of intra-programmatic collaborations, 15% were inter-programmatic. Members participate in a monthly luncheon seminar series to exchange research results. The Cancer Center adds value to the research projects in CBS by providing shared facilities, consultation on state of the art technologies, human tissue samples, seed grants for translational research, and recruitment of outstanding investigators to Cancer Center Programs.
The mission of the Moores Cancer Center is to translate research discoveries into meaningful advances to prevent, ameliorate and eliminate the burden of cancer. Members of the Cancer Biology and Signaling Program conduct basic research on the biological processes that underlie the initiation and progression of Cancer.
Dow, Michelle; Pyke, Rachel M; Tsui, Brian Y et al. (2018) Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888 |
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306 |
Murzin, Vyacheslav L; Woods, Kaley; Moiseenko, Vitali et al. (2018) 4? plan optimization for cortical-sparing brain radiotherapy. Radiother Oncol 127:128-135 |
Norton, Jeffrey A; Kim, Teresa; Kim, Joseph et al. (2018) SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors. J Gastrointest Surg 22:32-42 |
Ikeda, Sadakatsu; Tsigelny, Igor F; Skjevik, Åge A et al. (2018) Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. Oncologist 23:586-593 |
Buckley, Alexandra R; Ideker, Trey; Carter, Hannah et al. (2018) Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas. Genome Med 10:69 |
Parish, Austin J; Nguyen, Vi; Goodman, Aaron M et al. (2018) GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers. Cancer 124:4080-4089 |
Xu, Selene; Thompson, Wesley; Ancoli-Israel, Sonia et al. (2018) Cognition, quality-of-life, and symptom clusters in breast cancer: Using Bayesian networks to elucidate complex relationships. Psychooncology 27:802-809 |
Tao, Li; Schwab, Richard B; San Miguel, Yazmin et al. (2018) Breast Cancer Mortality in Older and Younger Breast Cancer Patients in California. Cancer Epidemiol Biomarkers Prev : |
Sagredo, Eduardo A; Blanco, Alejandro; Sagredo, Alfredo I et al. (2018) ADAR1-mediated RNA-editing of 3'UTRs in breast cancer. Biol Res 51:36 |
Showing the most recent 10 out of 862 publications