The mission of the Solid Tumor Therapeutics Program (STT) is to develop novel therapeutics and the diagnostic tools needed to individualize their use. The strategy for executing this mission involves a spectrum of basic, translational and clinical research efforts directed toward the identification of susceptible molecular targets, and validation of their importance to tumor behavior; the identification and preclinical testing of potential new drugs and diagnostics that can guide their use/ and, the clinical testing of new drugs, diagnostics and therapeutic strategies. The STT program is organized around 4 major research themes: inflammation and cancer, angiogenesis and metastasis, drug discovery, development targentin and teseing; and imaging development The STT Program has 82 members from 18 academic departments with $18.9 Million in peer review research grant funding (annual direct costs), including $7.6 Million from NCI. STT members published 1391 programmatically aligned articles (2007-2012); 10% were the result of intraprogrammatic collaborations, 11% were interprogrammatic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023100-30
Application #
9070316
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
30
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Nguyen, Vi; Marmor, Rebecca A; Ramamoorthy, Sonia L et al. (2018) The Use of Solicited Publishing by Academic Surgeons. Surgery 164:212-218
Yan, Wei; Wu, Xiwei; Zhou, Weiying et al. (2018) Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol 20:597-609
Pandolfi, Erica C; Hoffmann, Hanne M; Schoeller, Erica L et al. (2018) Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55:8709-8727
Galanina, Natalie; Goodman, Aaron M; Cohen, Philip R et al. (2018) Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade. Cancer Immunol Res 6:1129-1135
Chin, Andrew R; Yan, Wei; Cao, Minghui et al. (2018) Polarized Secretion of Extracellular Vesicles by Mammary Epithelia. J Mammary Gland Biol Neoplasia 23:165-176
Garcia, Daniel A; Baek, Christina; Estrada, M Valeria et al. (2018) USP11 Enhances TGF?-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis. Mol Cancer Res 16:1172-1184
Jiang, Qingfei; Jamieson, Catriona (2018) BET'ing on Dual JAK/BET Inhibition as a Therapeutic Strategy for Myeloproliferative Neoplasms. Cancer Cell 33:3-5
Ramirez, Oscar; Aristizabal, Paula; Zaidi, Alia et al. (2018) Implementing a Childhood Cancer Outcomes Surveillance System Within a Population-Based Cancer Registry. J Glob Oncol :1-11
Liu, Liang; Yang, Lin; Yan, Wei et al. (2018) Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis. Clin Cancer Res 24:2370-2382
Lwin, Thinzar M; Murakami, Takashi; Miyake, Kentaro et al. (2018) Tumor-Specific Labeling of Pancreatic Cancer Using a Humanized Anti-CEA Antibody Conjugated to a Near-Infrared Fluorophore. Ann Surg Oncol 25:1079-1085

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