Abstract

Purdue University is committed to the development of a multidisciplinary program for experimental cancer research with focus on the elucidation of the biological and biochemical events involved in cell transformation as the basis for new approaches to the prevention, diagnosis and chemical therapy of cancer. Ours is a specialized Cancer Center whose primary objectives are to correlate and integrate existing programs in cancer research at Purdue University, to stimulate new research in selected areas, to contribute to advanced training in cancer research, and to develop interactions among Purdue researchers, local physicians, hospitals and clinics and cancer researchers at other universities and research laboratories within the State of Indiana. This request is for a continuation of partial support for the administrative functions and the shared resources and services provided by the center as well as for center development and planning activities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-08
Application #
3101727
Study Section
Cancer Center Support Grant Review Committee (CCS)
Project Start
1978-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Type
Organized Research Units
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
Thompson, Taylor J; Han, Bumsoo (2018) Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform. Biomicrofluidics 12:042215
Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Kumari, Rashmi; Silic, Martin R; Jones-Hall, Yava L et al. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget 9:23494-23504
Larocque, Elizabeth A; Naganna, N; Opoku-Temeng, Clement et al. (2018) Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase. ChemMedChem 13:1172-1180
Poh, Scott; Chelvam, Venkatesh; Ayala-López, Wilfredo et al. (2018) Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases. Nanomedicine 14:1033-1043
VerHeul, Ross; Sweet, Craig; Thompson, David H (2018) Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction. Biomater Sci 6:863-876
AlAbdi, Lama; He, Ming; Yang, Qianyi et al. (2018) The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells. J Biol Chem 293:11109-11118
Coleman, Rachel A; Trader, Darci J (2018) A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome. Curr Protoc Chem Biol 10:e52
Liu, Yunhua; Xu, Hanchen; Van der Jeught, Kevin et al. (2018) Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. J Clin Invest 128:2951-2965

Showing the most recent 10 out of 436 publications