The Purdue University Center for Cancer Research was established in 1978 as an NCI-designated basic Cancer Research Center. The Center capitalizes on Purdue's nationally recognized strengths in engineering, chemistry and the biological sciences to focus institutional transdisciplinary expertise on the cancer problem. The interface among the diverse scientific specialties is exploited in inter- and intraprogrammatic collaborations that the Center fosters, and this represents a fundamental and unique strength of this Center. The Center's four scientific programs integrate chemical design and synthesis (Medicinal Chemistry Program), protein structural analysis (Chemical and Structural Biology Program), development of new molecules and materials for cancer detection, delivery of therapeutics (Drug Design and Molecular Sensing Program) and molecular mechanisms of cell growth (Cell Growth and Differentiation Program) to form a network of collaborative science that crosses multiple disciplines. The synergism generated by the Center Programs derives from the Center's focus on transdisciplinary research as the key to progress in controlling cancer. In addition to its scientific programs, the Center fosters fundamental cancer research through six Center-sponsored discovery groups, a Pilot Grants Program, retreats and seminar programs. The four scientific programs are served by seven shared resources: Flow Cytometry and Cell Separation;DNA Sequencing;Proteomics;Macromolecular Crystallography;Mass Spectrometry;Nuclear Magnetic Resonance;and Transgenic Mouse. The Center for Cancer Research Support Grant also provides funds for the strategic recruitment of new cancer-focused investigators to the Center, for planning and evaluation, and for administration and organization of the Center. Relevance: The Purdue University Center for Cancer Research brings together investigators from multiple disciplines to address important cancer questions. Leaders in the Center provide resources and organizational capacity that enable the pursuit of collaborative research. The collaborative efforts generate transdisciplinary investigations that lead to novel discoveries, which improve in early detection and care of cancer patients.

Public Health Relevance

The Purdue University Center for Cancer Research brings together investigators from multiple disciplines to address important cancer questions. Leaders in the Center provide resources and organizational capacity that enable the pursuit of collaborative research. The collaborative efforts generate transdisciplinary investigations that lead to novel discoveries, which improve in early detection and care of cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-31
Application #
8139094
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ptak, Krzysztof
Project Start
1997-04-01
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
31
Fiscal Year
2011
Total Cost
$1,195,345
Indirect Cost
Name
Purdue University
Department
Type
Organized Research Units
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
VerHeul, Ross; Sweet, Craig; Thompson, David H (2018) Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction. Biomater Sci 6:863-876
Poh, Scott; Chelvam, Venkatesh; Ayala-López, Wilfredo et al. (2018) Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases. Nanomedicine 14:1033-1043
Coleman, Rachel A; Trader, Darci J (2018) A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome. Curr Protoc Chem Biol 10:e52
AlAbdi, Lama; He, Ming; Yang, Qianyi et al. (2018) The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells. J Biol Chem 293:11109-11118
Lee, Hyeong-Min; Clark, Ellen P; Kuijer, M Bram et al. (2018) Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome. Mol Autism 9:45
Liu, Yunhua; Xu, Hanchen; Van der Jeught, Kevin et al. (2018) Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. J Clin Invest 128:2951-2965
Hall, Hana; Ma, Jingqun; Shekhar, Sudhanshu et al. (2018) Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors. BMC Neurosci 19:43
Weaver, Cory J; Terzi, Aslihan; Roeder, Haley et al. (2018) nox2/cybb Deficiency Affects Zebrafish Retinotectal Connectivity. J Neurosci 38:5854-5871
Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Chambers, Andrea M; Lupo, Kyle B; Matosevic, Sandro (2018) Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells. Front Immunol 9:2517

Showing the most recent 10 out of 436 publications