Abstract

The analysis of macromolecular structures by X ray crystallography provides data critical for understanding the beneficial and adverse functions of biological macromolecules and assemblies associated with cancer, which is a research focus of the Purdue University Center for Cancer Research's Chemical and Structural Biology Scientific Program. The Macromolecular Crystallography Shared Resource was established in 1998 and promotes cancer-related crystallographic research by ensuring the continuous availability of advanced facilities for crystallization and x-ray diffraction as well as the technical guidance necessary for their optimal use. The Macromolecular Crystallography Shared Resource provides essential services to the Chemical and Structural Biology Scientific Program in the Purdue University Center for Cancer Research and provides local, continuously available support to the internationally acclaimed research by Center for Cancer research crystallographers.

Public Health Relevance

The role of the shared resource is to assist individual investigators and scientific Programs within the Center that are seeking novel approaches to addressing a variety of cancer-related issues. In offering these key services, the shared resource provides the expertise necessary for achieving the next challenge;challenges that when solved will aid in reducing the pain and suffering of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-33
Application #
8470577
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
33
Fiscal Year
2013
Total Cost
$67,748
Indirect Cost
$23,351

  Institution

Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Onel, Buket; Carver, Megan; Agrawal, Prashansa et al. (2018) The 3'-end region of the human PDGFR-? core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes. Biochim Biophys Acta Gen Subj 1862:846-854
Sorlien, Erin L; Witucki, Mary A; Ogas, Joseph (2018) Efficient Production and Identification of CRISPR/Cas9-generated Gene Knockouts in the Model System Danio rerio. J Vis Exp :
Mani, Saravana Kumar Kailasam; Andrisani, Ourania (2018) Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma. Cytokine :
Dong, Cheng; Dong, Guangping; Li, Li et al. (2018) An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Commun Biol 1:183
Morman, Rosemary E; Schweickert, Patrick G; Konieczny, Stephen F et al. (2018) BATF regulates the expression of Nfil3, Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice. Eur J Immunol 48:1492-1505
Zhang, Zhuangzhuang; Cheng, Lijun; Li, Jie et al. (2018) Inhibition of the Wnt/?-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer. Cancer Res 78:3147-3162
Rangasamy, Loganathan; Chelvam, Venkatesh; Kanduluru, Ananda Kumar et al. (2018) New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange. Bioconjug Chem 29:1047-1059
Zhang, Hao; Zhang, Yanqiu; Zhu, Xiaoyun et al. (2018) DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology :
Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985
Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112

Showing the most recent 10 out of 436 publications