The Purdue University Center for Cancer Research was established in 1978 as an NCI-designated basic Cancer Research Center. The Center capitalizes on Purdue's nationally recognized strengths in engineering, chemistry and the biological sciences to focus institutional transdisciplinary expertise on the cancer problem. The interface among the diverse scientific specialties is exploited in inter- and intraprogrammatic collaborations that the Center fosters, and this represents a fundamental and unique strength of this Center. The Center's four scientific programs integrate chemical design and synthesis (Medicinal Chemistry Program), protein structural analysis (Chemical and Structural Biology Program), development of new molecules and materials for cancer detection, delivery of therapeutics (Drug Design and Molecular Sensing Program) and molecular mechanisms of cell growth (Cell Growth and Differentiation Program) to form a network of collaborative science that crosses multiple disciplines. The synergism generated by the Center Programs derives from the Center's focus on transdisciplinary research as the key to progress in controlling cancer. In addition to its scientific programs, the Center fosters fundamental cancer research through six Center-sponsored discovery groups, a Pilot Grants Program, retreats and seminar programs. The four scientific programs are served by seven shared resources: Flow Cytometry and Cell Separation;DNA Sequencing;Proteomics;Macromolecular Crystallography;Mass Spectrometry;Nuclear Magnetic Resonance;and Transgenic Mouse. The Center for Cancer Research Support Grant also provides funds for the strategic recruitment of new cancer-focused investigators to the Center, for planning and evaluation, and for administration and organization of the Center. Relevance: The Purdue University Center for Cancer Research brings together investigators from multiple disciplines to address important cancer questions. Leaders in the Center provide resources and organizational capacity that enable the pursuit of collaborative research. The collaborative efforts generate transdisciplinary investigations that lead to novel discoveries, which improve in early detection and care of cancer patients.

Public Health Relevance

The Purdue University Center for Cancer Research brings together investigators from multiple disciplines to address important cancer questions. Leaders in the Center provide resources and organizational capacity that enable the pursuit of collaborative research. The collaborative efforts generate transdisciplinary investigations that lead to novel discoveries, which improve in early detection and care of cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA023168-34S1
Application #
8856693
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Ogunbiyi, Peter
Project Start
1997-04-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Organized Research Units
DUNS #
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985
Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112
Dhawan, Deepika; Hahn, Noah M; Ramos-Vara, José A et al. (2018) Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet 14:e1007571
Shinde, Aparna; Libring, Sarah; Alpsoy, Aktan et al. (2018) Autocrine Fibronectin Inhibits Breast Cancer Metastasis. Mol Cancer Res 16:1579-1589
Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
Thompson, Taylor J; Han, Bumsoo (2018) Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform. Biomicrofluidics 12:042215
Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Larocque, Elizabeth A; Naganna, N; Opoku-Temeng, Clement et al. (2018) Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase. ChemMedChem 13:1172-1180
Kumari, Rashmi; Silic, Martin R; Jones-Hall, Yava L et al. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget 9:23494-23504
VerHeul, Ross; Sweet, Craig; Thompson, David H (2018) Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction. Biomater Sci 6:863-876

Showing the most recent 10 out of 436 publications