Abstract

Biomolecular Structure Shared Resource (BS-SR): Project Summary Determination of macromolecular structures and their complexes with small molecule drugs by X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy is paramount to understanding biological processes and disease at the molecular level and to the rational design of highly selective therapeutic agents. Accordingly, the primary mission of the Biomolecular Structure Shared Resource (BS-SR) is to provide Purdue University Center for Cancer Research (PCCR) members with facilitated access to state-of-the-art technologies, hardware and expertise across a wide range of structural biology modalities that will allow them to investigate cancer mechanisms and to perform iterative, structure-based design of anti-cancer therapeutics. By providing PCCR members with services and instrument time at a lower cost, PCCR members can also more efficiently use their research funds, further enhancing their competitiveness in obtaining peer-reviewed funding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023168-40
Application #
10024908
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-08-01
Budget End
2021-06-30
Support Year
40
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Rangasamy, Loganathan; Chelvam, Venkatesh; Kanduluru, Ananda Kumar et al. (2018) New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange. Bioconjug Chem 29:1047-1059
Zhang, Hao; Zhang, Yanqiu; Zhu, Xiaoyun et al. (2018) DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology :
Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985
Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112
Dhawan, Deepika; Hahn, Noah M; Ramos-Vara, José A et al. (2018) Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet 14:e1007571
Shinde, Aparna; Libring, Sarah; Alpsoy, Aktan et al. (2018) Autocrine Fibronectin Inhibits Breast Cancer Metastasis. Mol Cancer Res 16:1579-1589
Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita et al. (2018) Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. Bioorg Med Chem Lett 28:2605-2610
Thompson, Taylor J; Han, Bumsoo (2018) Analysis of adhesion kinetics of cancer cells on inflamed endothelium using a microfluidic platform. Biomicrofluidics 12:042215
Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Kumari, Rashmi; Silic, Martin R; Jones-Hall, Yava L et al. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget 9:23494-23504

Showing the most recent 10 out of 436 publications