The long-term objective of the Cancer Center's Chemical Library Screening Facility is to provide new chemical tools for elucidating the basic mechanisms that underlie tumor onset and progression, and to provide lead chemical compounds for initiation of the development of anti-tumor drugs. Small molecule agonists and antagonists have proven to be invaluable tools for solving problems in biology. Since high-throughput screening is not widely available at academic institutions, this facility will provide a new and unique approach toward understanding and combating cancer. The Cancer Center's Chemical Library Screening Facility was founded in mid-2002. The facility was built with funds provided by the Institute and from the fund-raising efforts of Principle Investigators. At the present time the Facility is not funded by the CCSG. The rapid success of the Facility, and the anticipated heavy demand for its services provide the rationale for the funding that is requested.
The Specific Aims of the Chemical Library Screening Facility are to: 1) Establish and maintain a large chemical library, and an accompanying database, for screening against molecular targets in cancer; 2) Provide consultation to the Faculty of the Cancer Center in the design of high-throughput assays; 3) Provide high throughput screening services to the Faculty of the Cancer Center; and 4) Provide virtual screening capabilities to the Faculty of the Cancer Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA030199-24
Application #
6990472
Study Section
Subcommittee G - Education (NCI)
Project Start
2004-06-28
Project End
2009-04-30
Budget Start
2004-06-28
Budget End
2005-04-30
Support Year
24
Fiscal Year
2004
Total Cost
$134,665
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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