The goal of the Functional Genomics Core (FGC) is to provide a comprehensive, integrated approach togenomics research for Cancer Center investigators. Presently, the FGC provides a range of Microarray andData Analysis Services. The microarray gene expression profiling service is based on the Affymetrixoligonucleotide array platform of GeneChips. Basic and advanced data analysis is provided bybiostatisticians and bioinformaticists in conjunction with the Biomedical Informatics Core. The FGC iscurrently undergoing expansion to provide two new major services, RNAi-based technology and genotyping.The former allows functional analyses of genes using approaches such as siRNA, and latter providesmoderate-throughput SNP and DMA methylation analyses. All of the FGC services are provided by highlyexperienced Core Managers with extensive expertise in their areas of specialization. Cohesiveness andsynergy among all of the FGC components are provided by the Scientific Director, who leads regularmeetings with all Core Managers to discuss assay development, data analysis, trouble-shooting, integration,and new techniques. The Core Managers provide advice to investigators on experimental design prior tolaboratory and clinical studies, assay development and quality control during the studies and interpretation ofdata generated by the Core. This 'one-stop shopping' approach makes functional genomics research morebroadly accessible to Cancer Center investigators. Thus, the FGC provides advanced technologies andsupport for basic, clinical and population studies that enhance functional genomics research andcollaborations across all COHCCC programs. During the prior 12-month reporting period, the FGC wasused by 14 Cancer Center members from all 5 Research Programs; peer-reviewed usage represented 76%of the total. The proposed total annual budget is $339,788, representing 39% institutional support, 18% userfees, 16% other, and 27% ($91,000) requested from the CCSG.
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