Cancer Control and Population Sciences Program ABSTRACT The mission of the Cancer Control and Population Sciences (CCPS) Program is to advance the science and application of cancer etiology, prevention, and outcomes research. The goal is to reduce the burden of cancer and its sequelae across all segments of the population through collaborative, multidisciplinary efforts. To achieve this goal, the Program has three themes: 1) To discover host and environmental factors contributing to cancer; 2) To identify factors to reduce health-related morbidity and mortality from cancer treatment; and 3) To develop, implement and evaluate interventions to reduce cancer-related morbidity/mortality and improve quality of life (QOL). Within each of these themes, research is on-going to reduce health disparities within our catchment area. As importantly, each theme encompasses strong education components ranging from K-12 programs in the community to healthcare provider and caregiver training for better communication and care for cancer survivors. Targeted recruits with national prominence add both depth and breadth to the Program and include Drs. Seewaldt, Chlebowski, Gray, Kittles, and Yee. The CCPS Program is particularly invested in the following key areas: building a robust portfolio of research in cancer etiology and biomarker development; strengthening the focus on understanding risk factors for treatment-related complications and developing tailored interventions to reduce morbidity in cancer survivors; recognizing causes of disparities in outcome unique to disease type and developing tailored interventions to systematically mitigate the disparities; and continuing to build upon the strong portfolio of research in psychosocial outcomes and tailored interventions to improve QOL. Sponsored activities include monthly work in progress meetings, monthly seminars, an annual retreat, and annual pilot funding. Membership: 23 Program Members representing 4 basic and clinical departments Publications: 410 total. 34.6% intra-programmatic; 20.2% inter-programmatic; 58.0% inter-institutional Funding: $7,770,700 peer-reviewed; $5,788,708 of which is NCI funding

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA033572-38
Application #
10059210
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
1997-08-01
Project End
2022-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
38
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Yoon, Sorah; Wu, Xiwei; Armstrong, Brian et al. (2018) An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFR? Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. Mol Ther Nucleic Acids 14:131-141
Gast, Charles E; Silk, Alain D; Zarour, Luai et al. (2018) Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival. Sci Adv 4:eaat7828
Salgia, Ravi; Kulkarni, Prakash (2018) The Genetic/Non-genetic Duality of Drug 'Resistance' in Cancer. Trends Cancer 4:110-118
Magilnick, Nathaniel; Boldin, Mark P (2018) Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate. Curr Stem Cell Rep 4:158-165
Yim, John H; Choi, Audrey H; Li, Arthur X et al. (2018) Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics. Clin Cancer Res :
Wang, Tianyi; Fahrmann, Johannes Francois; Lee, Heehyoung et al. (2018) JAK/STAT3-Regulated Fatty Acid ?-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. Cell Metab 27:136-150.e5
Slavin, Thomas P; Banks, Kimberly C; Chudova, Darya et al. (2018) Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing. J Clin Oncol :JCO1800328
Yun, Xinwei; Zhang, Keqiang; Wang, Jinhui et al. (2018) Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma. Mol Cancer Res 16:1161-1171
Herrera, Alex F; Rodig, Scott J; Song, Joo Y et al. (2018) Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma. Biol Blood Marrow Transplant 24:514-520
Oh, Eunjin; Ahn, Miwon; Afelik, Solomon et al. (2018) Syntaxin 4 Expression in Pancreatic ?-Cells Promotes Islet Function and Protects Functional ?-Cell Mass. Diabetes 67:2626-2639

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