Abstract

The Jackson Laboratory (TJL) was founded in 1929 by Dr. Clarence Cook Little as a mammalian genetics research center focusing on the problem of cancer. The long term goal of TJL Cancer Center program is to contribute to basic understanding of the genetic determinants of cancer. Expertise in the genetics and biology of the laboratory mouse is the predominant strength of TJL Cancer Center and is the centerpiece of the cancer research conducted here. The mouse represents a powerful mammalian model for human genetic organization and regulation, modes of inheritance, and disease. Researchers are identifying sets of associated genes participating in complex diseases and beginning to elucidate their modes of interaction. Epigenetic factors influencing gene action, mutagenesis, and cancer risk are being isolated and identified. Other investigators are discovering the molecular regulation of developmental processes, the dysregulation of which can lead to cellular transformation. A wide array of inbred, congenic, and mutant strains of mice are available for investigations into the control of immune functions and development of immunotherapies for cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA034196-16
Application #
2748695
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Vembu, Devi
Project Start
1996-08-25
Project End
2001-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
16
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Becker, Timothy; Lee, Wan-Ping; Leone, Joseph et al. (2018) FusorSV: an algorithm for optimally combining data from multiple structural variation detection methods. Genome Biol 19:38
Wang, Qianghu; Hu, Baoli; Hu, Xin et al. (2018) Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell 33:152
Richter, Wolfgang F; Christianson, Gregory J; Frances, Nicolas et al. (2018) Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice. MAbs 10:803-813
Tamura, Ryo; Yoshihara, Kosuke; Saito, Tetsuya et al. (2018) Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions. Oncogenesis 7:4
Rutherford, Sarah C; Fachel, Angela A; Li, Sheng et al. (2018) Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations. Blood 132:e13-e23
Barthel, Floris P; Wesseling, Pieter; Verhaak, Roel G W (2018) Reconstructing the molecular life history of gliomas. Acta Neuropathol 135:649-670
Kim, Hyunsoo; Kumar, Pooja; Menghi, Francesca et al. (2018) High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts. Sci Rep 8:17937
Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:
Barthel, Floris P; Johnson, Kevin C; Wesseling, Pieter et al. (2018) Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults. Neurol Clin 36:421-437
Schechter, Lisa M; Creely, David P; Garner, Cherilyn D et al. (2018) Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli. MBio 9:

Showing the most recent 10 out of 1156 publications