Abstract

The Cryopreservation and Rederivation programs of The Jackson Laboratory (TJL) serve TJL Cancer Center members by ensuring that all strains imported to TJL are free of potential infectious pathogens and that research strains are cryopreserved to ensure continued availability and to guard against accidental loss. Both of these programs utilize state-of-the art reproductive technology in a new facility designed for optimal integrated functionality and both programs are absolutely essential to our operation as a research laboratory focused on mammalian genetics. In this application funds are requested to support: 1) the importation of approximately 50 strains per year for individual TJL Cancer Center members, 2) the rederivation of strains within the Research Animal Facility as part of a program to operate the facility as a barrier facility with all animals at uniform health status; and 3) the cryopreservation of approximately 40 strains developed or acquired by TJL Cancer Center members per year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA034196-20
Application #
6652227
Study Section
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
20
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Vian, Laura; P?kowska, Aleksandra; Rao, Suhas S P et al. (2018) The Energetics and Physiological Impact of Cohesin Extrusion. Cell 173:1165-1178.e20
Tarchini, Basile; Longo-Guess, Chantal; Tian, Cong et al. (2018) A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development. Dev Biol 443:153-164
Garrett, Andrew M; Khalil, Andre; Walton, David O et al. (2018) DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members. Proc Natl Acad Sci U S A 115:E10216-E10224
Huang, Bin; Jia, Dongya; Feng, Jingchen et al. (2018) RACIPE: a computational tool for modeling gene regulatory circuits using randomization. BMC Syst Biol 12:74
Hua, Li; Shi, Jiayuan; Shultz, Leonard D et al. (2018) Genetic Models of Macrophage Depletion. Methods Mol Biol 1784:243-258
Chae, Young Kwang; Anker, Jonathan F; Bais, Preeti et al. (2018) Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma. Oncotarget 9:7949-7960
Greathouse, K Leigh; White, James R; Vargas, Ashely J et al. (2018) Interaction between the microbiome and TP53 in human lung cancer. Genome Biol 19:123
Bocci, Federico; Suzuki, Yoko; Lu, Mingyang et al. (2018) Role of metabolic spatiotemporal dynamics in regulating biofilm colony expansion. Proc Natl Acad Sci U S A 115:4288-4293
Noorbakhsh, Javad; Kim, Hyunsoo; Namburi, Sandeep et al. (2018) Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power. Sci Rep 8:11445
Gong, Liang; Wong, Chee-Hong; Cheng, Wei-Chung et al. (2018) Picky comprehensively detects high-resolution structural variants in nanopore long reads. Nat Methods 15:455-460

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