Phenotyping Sciences provides Cancer Center faculty with diverse tools, techniques and expertise for theconduct of gene expression, molecular biology, flow cytometry, and protein chemistry methods. Created asa result of the reorganization of Scientific Services in 2004, this department comprises the formerMicrochemistry and Flow Cytometry Services. Microchemistry has been supported by the Cancer CenterSupport Grant since the Service was developed 17 years ago, while Flow Cytometry has been supportedfor the full 23-year term of the grant. The Phenotyping Sciences Service provides researchers with accessto state-of-the-art gene expression technologies, nucleic acid isolation and quality assessment, genetargeting and transgenic construct design, protein chemistry services, advanced flow cytometric technologyand a monoclonal antibody resource. Access to these services is essential to Cancer Center staff. Overalluse of the Phenotyping Sciences Service has increased by 55% over the past five years. The PhenotypingSciences Project Leader, Senior Staff Scientist Dr. Derry Roopenian, oversees this fee-for-serviceoperation. Three gene expression technologists, two flow cytometrists, three molecular biologists, a proteinchemist, and senior manager staff the facility which occupies 1,851 ft2 of laboratory space in the ResearchLaboratory Unit 4 building. The Service is dynamic, continuously increasing and improving its array ofservices to meet the needs of the Cancer Center members. Since the last renewal, significantadvancements in technology have provided for the expansion and improvement of multi-color flowcytometry and sorting, gene expression microarray analysis, and multiplexed protein assay services.Phenotyping Sciences is completely integrated with the other services at the Center, includingComputational Sciences, Reproductive Sciences-Cell Biology and Microinjection, and SNP Genotyping toprovide a comprehensive set of support services for cancer research. Dr. Roopenian communicates withthe Cancer Center users, Service staff and Center Administration to ensure that research needs are met inthe most efficient, cost-effective and technically current manner.
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