Abstract

The NMR Shared Resource provides the infrastructure for the acquisition of NMR data and the determination of structures of biological molecules. The Varian INOVA 500-MHz NMR magnet, with its new console and probes are located in room 1009 of the Eppley Science Hall. The new Varian INOVA 600-MHz instrument is in the adjacent room (1010 ESH) and the two rooms have been connected with an opening. The 500-MHz NMR instrument has been upgraded with a new console and associated probes to make it state-of-the-art and compatible with the 600 instrument. A cold probe has been ordered for the 600 instrument, which will provide a significant increase in signal to noise and sensitivity. The facility is directed by Dr. Gus Wang (Assistant Professor, Eppley Institute, UNMC), with the support of Paul Keifer, Ph.D. (Research Assistant Professor, Eppley Institute), who maintains the infrastructure and provides user support. Cancer Center members with peer-reviewed funding account for 18% of the facility's usage.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-22
Application #
7287317
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
22
Fiscal Year
2006
Total Cost
$38,535
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Neilsen, Beth K; Chakraborty, Binita; McCall, Jamie L et al. (2018) WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage. BMC Cancer 18:673
Schopfer, Lawrence M; Lockridge, Oksana (2018) Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity. J Biol Chem 293:13566-13577
Baranovskiy, Andrey G; Duong, Vincent N; Babayeva, Nigar D et al. (2018) Activity and fidelity of human DNA polymerase ? depend on primer structure. J Biol Chem 293:6824-6843
Khadge, Saraswoti; Sharp, John Graham; Thiele, Geoffrey M et al. (2018) Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology. J Nutr Biochem 52:92-102
Kuss, Mitchell; Kim, Jiyoung; Qi, Dianjun et al. (2018) Effects of tunable, 3D-bioprinted hydrogels on human brown adipocyte behavior and metabolic function. Acta Biomater 71:486-495
Ingersoll, Matthew A; Chou, Yu-Wei; Lin, Jamie S et al. (2018) p66Shc regulates migration of castration-resistant prostate cancer cells. Cell Signal 46:1-14
Svechkarev, Denis; Kyrychenko, Alexander; Payne, William M et al. (2018) Development of colloidally stable carbazole-based fluorescent nanoaggregates. J Photochem Photobiol A Chem 352:55-64
Ambardekar, Vishakha V; Wakaskar, Rajesh R; Ye, Zhen et al. (2018) Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration. Int J Pharm 543:130-138
Tian, Tian; Bi, Chengfeng; Hein, Ashley L et al. (2018) Rac1 is a novel therapeutic target in mantle cell lymphoma. Blood Cancer J 8:17
Saxena, Sugandha; Purohit, Abhilasha; Varney, Michelle L et al. (2018) Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells. BMC Cancer 18:1283

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