Abstract

UNMC Advanced Microscopy Core Facility (UAMCF) The UNMC Advanced Microscopy Core Facility (UAMCF) at the University of Nebraska Medical Center is dedicated to providing top-notch microscopy and imaging services for competitive fees. Over the past funding period, the UAMCF has undergone a leadership change with a new Director who is committed to developing and maintaining a world-class microscopy facility with cutting-edge technologies to drive innovative research at UNMC. UAMCF has recently obtained a dual-platform super-resolution microscope with capabilities for super- resolution Structured Illumination Microscopy (sr-SIM) and single-molecule Photoactivatible Localization Microscopy/direct Stochastic Optical Reconstruction Microscopy. Sr-SIM capabilities include up to 100 nm resolution in the x/y axis, and ~300 nm axial resolution. PALM/dSTORM capabilities include single-molecule imaging and precision of ~5 nm coupled with ~10 nm Nyquiste Resolution. The facility provides outstanding service, including consultations by active researchers with expertise who have published studies using advanced microscopy techniques. Coupled with standard confocal microscopy provided by the facility, the UAMCF provides outstanding support for Cancer Center and other researchers on campus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-34
Application #
9981644
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-09-05
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
34
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Kumar, Vinod; Kumar, Virender; Chaudhary, Amit Kumar et al. (2018) Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis. Mol Ther Nucleic Acids 12:490-503
Huang, Yunlong; Li, Yuju; Zhang, Hainan et al. (2018) Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869. Cell Discov 4:19
Baranovskiy, Andrey G; Siebler, Hollie M; Pavlov, Youri I et al. (2018) Iron-Sulfur Clusters in DNA Polymerases and Primases of Eukaryotes. Methods Enzymol 599:1-20
Fan, Wei; Zhang, Wenting; Alshehri, Sameer et al. (2018) Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents. Chem Commun (Camb) 54:11268-11271
Robb, Caroline M; Kour, Smit; Contreras, Jacob I et al. (2018) Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy. Oncotarget 9:5216-5232
Ouellette, Scot P; Messerli, Parker R; Wood, Nicholas A et al. (2018) Characterization of Chlamydial Rho and the Role of Rho-Mediated Transcriptional Polarity during Interferon Gamma-Mediated Tryptophan Limitation. Infect Immun 86:
Attri, Kuldeep S; Mehla, Kamiya; Shukla, Surendra K et al. (2018) Microscale Gene Expression Analysis of Tumor-Associated Macrophages. Sci Rep 8:2408
Souchek, Joshua J; Wojtynek, Nicholas E; Payne, William M et al. (2018) Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft. Acta Biomater 75:323-333
Wipfler, Kristin; Cornish, Adam S; Guda, Chittibabu (2018) Comparative molecular characterization of typical and exceptional responders in glioblastoma. Oncotarget 9:28421-28433
Saxena, Ashima; Belinskaya, Tatyana; Schopfer, Lawrence M et al. (2018) Characterization of butyrylcholinesterase from porcine milk. Arch Biochem Biophys 652:38-49

Showing the most recent 10 out of 1372 publications