Abstract

The Huntsman Cancer Institute (HCI) is committed to the development of new approaches to reducing the morbidity and mortality due to cancer. The main focus is on the major adult epithelial tumors, breast, prostate, colon, and aerodigestive. A major research theme of the HCI is the development of new approaches to very early diagnosis and treatment based on the emerging knowledge of the earliest molecular changes in tumorigenesis. This builds on our traditional strength in molecular genetics, which has opened a window into the earliest changes in carcinogenesis. Traditional, discipline-oriented Programs will continue to underlie our primary organizational structure. However, our primary approach will be implemented through a series of new, interdisciplinary, translational Programs focused on the molecular genetics, biology, diagnosis, and therapy of the individual tumor types.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA042014-11S1
Application #
2800613
Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Vembu, Devi
Project Start
1986-07-01
Project End
1999-04-30
Budget Start
1997-05-09
Budget End
1999-04-30
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Barrott, Jared J; Illum, Benjamin E; Jin, Huifeng et al. (2018) Paracrine osteoprotegerin and ?-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest 128:207-218
Sample, Danielle C; Samadder, N Jewel; Pappas, Lisa M et al. (2018) Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients. BMC Gastroenterol 18:115
Delker, Don A; Wood, Austin C; Snow, Angela K et al. (2018) Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia. Cancer Prev Res (Phila) 11:4-15
Madsen, Michael J; Knight, Stacey; Sweeney, Carol et al. (2018) Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15. Cancer Epidemiol Biomarkers Prev 27:644-652
Trott, Daniel W; Henson, Grant D; Ho, Mi H T et al. (2018) Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp Gerontol 109:99-107
Wu, Yelena P; Parsons, Bridget G; Mooney, Ryan et al. (2018) Barriers and Facilitators to Melanoma Prevention and Control Behaviors Among At-Risk Children. J Community Health 43:993-1001
Zabriskie, Matthew S; Antelope, Orlando; Verma, Anupam R et al. (2018) A novel AGGF1-PDGFRb fusion in pediatric T-cell acute lymphoblastic leukemia. Haematologica 103:e87-e91
Wolff, Roger K; Hoffman, Michael D; Wolff, Erica C et al. (2018) Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. Genes Chromosomes Cancer 57:366-376
Hellwig, Sabine; Nix, David A; Gligorich, Keith M et al. (2018) Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing. PLoS One 13:e0197333
Fleming, Aaron M; Zhu, Judy; Ding, Yun et al. (2018) Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions. Biochemistry 57:991-1002

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