The primary goal of the Biostatistics Shared Resource (BSR) is to provide biostatistical and biomathematical support for basic, clinical and epidemiological studies that are underway in the Huntsman Cancer Institute's (HCI's) Cancer Center. The BSR provides a wide spectrum of services to the Cancer Center community, assisting basic and clinical investigators with study design, sample size/power calculations, data analyses, and preparation of presentations grant applications and manuscripts. Emphasis is placed on early consultation to allow adequate consideration of study designs specifically adapted to the main objectives of the study. For the past two years, a policy of the BSR has been to more actively seek collaborations suggested by recent developments in cancer-related biostatistical research and to respond to methodological challenges emerging from specific applications. This policy has proven to be quite fruitful and has resulted in substantially increased number of joint publications. It is expected that the demands for statistical consulting services will increase substantially in the coming years because of a rapid development of the Cancer Center and an increasing number of users who have clearly benefitted from the BSR assistance. In addition, a large project is underway in which the BSR will collaborate with the Microarray Resource in order to provide every user of the new microarray image technology with the needed quantitative analysis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA042014-12
Application #
6102271
Study Section
Project Start
1999-07-05
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Tavtigian, Sean V; Greenblatt, Marc S; Harrison, Steven M et al. (2018) Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework. Genet Med 20:1054-1060
Rogers, R Aaron; Fleming, Aaron M; Burrows, Cynthia J (2018) Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence. Biophys J 114:1804-1815
Rogers, R Aaron; Fleming, Aaron M; Burrows, Cynthia J (2018) Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters. ACS Omega 3:9630-9635
Wei, Xiaomu; Calvo-Vidal, M Nieves; Chen, Siwei et al. (2018) Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res 78:2747-2759
Barrott, Jared J; Illum, Benjamin E; Jin, Huifeng et al. (2018) Paracrine osteoprotegerin and ?-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest 128:207-218
Sample, Danielle C; Samadder, N Jewel; Pappas, Lisa M et al. (2018) Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients. BMC Gastroenterol 18:115
Delker, Don A; Wood, Austin C; Snow, Angela K et al. (2018) Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia. Cancer Prev Res (Phila) 11:4-15
Madsen, Michael J; Knight, Stacey; Sweeney, Carol et al. (2018) Reparameterization of PAM50 Expression Identifies Novel Breast Tumor Dimensions and Leads to Discovery of a Genome-Wide Significant Breast Cancer Locus at 12q15. Cancer Epidemiol Biomarkers Prev 27:644-652
Trott, Daniel W; Henson, Grant D; Ho, Mi H T et al. (2018) Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp Gerontol 109:99-107
Wu, Yelena P; Parsons, Bridget G; Mooney, Ryan et al. (2018) Barriers and Facilitators to Melanoma Prevention and Control Behaviors Among At-Risk Children. J Community Health 43:993-1001

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