The primary goal of the Biostatistics Shared Resource is to provide biostatistical and biomathematical support and collaboration for laboratory, translational, clinical, population, and epidemiological cancer studies underway at Huntsman Cancer Institute (HCI). The Biostatistics Resource enhances the scientific quality and sophistication of cancer research projects by providing tailored, professional consultation at all levels and stages of research. The Resource assists investigators with study design, sample size/power calculations, data analyses, grant applications, and manuscripts. Emphasis is placed on early consultation to allow adequate consideration and adaptation of study designs to meet the main objectives of the research. The Resource also provides educational outreach to Cancer Center members as needed, allowing investigators to better address their specific research problems. The Biostatistics Shared Resource, by virtue of its activities with a broad range of cancer investigators, is central to the Cancer Center's priorities. It is also a focal point of transdisciplinary cancer research, as it facilitates the collaborative work of basic, population, and clinical researchers from many departments. The primary research component of the Biostatistics Resource focuses on carcinogenesis modeling, on methodologies for high throughput genomics applicable to cancer pathways (such as microarray, ChlP-Seq, and Digital Gene Expression), and on methodologies for analysis of familial aspects of cancer. Use of this Shared Resource by the Cancer Center has increased substantially during the most recent cycle, and biostaticians have been involved in numerous important scientific discoveries. Kenneth Boucher, PhD, is the Resource Director and reports to HCI Senior Directors. Since the recent receipt of the University of Utah Clinical and Translational Science Award, Biostatistics is also now affiliated with the biostatistical component of that program. The Resource retains direct Cancer Center management, while the affiliation allows increased depth of expertise combined with increased interaction of institutional biostaticians and related academic activities. The Resource also has an established advisory committee, which regularly reviews structure, quality of service and research, as well as goals and needs. The Resource is housed in the HCI research building. In 2008, usage of the Shared Resource by the Cancer Center was 79 percent. Funds are requested from the CCSG to cover 15 percent ($74,806) of the proposed Biostatistics budget. The Resource is currently near capacity, although the 21 percent of non-Center use could be reprioritized to Cancer Center members should the need arise. Additionally, new recruitment efforts should soon add capacity to this Resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-23
Application #
8378951
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
23
Fiscal Year
2012
Total Cost
$67,061
Indirect Cost
$22,184
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Zeng, Tao; Fleming, Aaron M; Ding, Yun et al. (2018) Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA. J Org Chem 83:3973-3978
Himbert, Caroline; Ose, Jennifer; Nattenmüller, Johanna et al. (2018) Body fatness, adipose tissue compartments and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study. Cancer Epidemiol Biomarkers Prev :
Madison, Bethany J; Clark, Kathleen A; Bhachech, Niraja et al. (2018) Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. J Biol Chem 293:18624-18635
Arbeeva, Liubov S; Hanson, Heidi A; Arbeev, Konstantin G et al. (2018) How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database. Front Public Health 6:277
Patel, Ami B; Lange, Thoralf; Pomicter, Anthony D et al. (2018) Similar expression profiles in CD34+ cells from chronic phase chronic myeloid leukemia patients with and without deep molecular responses to nilotinib. Oncotarget 9:17889-17894
De, Shrutokirti; Van Deren, Donn; Peden, Eric et al. (2018) Two distinct ontogenies confer heterogeneity to mouse brain microglia. Development 145:
Giraddi, Rajshekhar R; Chung, Chi-Yeh; Heinz, Richard E et al. (2018) Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep 24:1653-1666.e7
Doherty, Jennifer A; Grieshober, Laurie; Houck, John R et al. (2018) Telomere Length and Lung Cancer Mortality among Heavy Smokers. Cancer Epidemiol Biomarkers Prev 27:829-837
Wagner, Alex H; Devarakonda, Siddhartha; Skidmore, Zachary L et al. (2018) Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Nat Commun 9:3787
Kleinstern, Geffen; Camp, Nicola J; Goldin, Lynn R et al. (2018) Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. Blood 131:2541-2551

Showing the most recent 10 out of 1193 publications