The primary goal of the DNA Sciences Core is to provide the Cancer Center research community of the University of Virginia with state of the art, cost-effective DNA associated services and reagents. In addition, the staff of the Core provides expertise to the Cancer Center members for experimental design and execution and data analysis and data mining. The scope of Core services includes nucleic acid synthesis and modification (boutique oligos), DNA sequencing, DNA fragment analysis or genotyping, and gene expression analyses with DNA microarray analysis (custom arrays and GeneChip?) and quantitative real time PCR. Data analysis, warehousing and community utilization of data are also a major function of the Core. The housing of these services together in the same Core provides for a seamless task-flow for projects, carried out in a cost-effective and expeditious manner. The staff maintains close interactions with the Cancer Center investigators in order to respond to the needs of the investigators by providing continuously updated protocols and reagents specifically tailored to meet Cancer Center members'research goals.
| Manukyan, Arkadi; Kowalczyk, Izabela; Melhuish, Tiffany A et al. (2018) Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors. J Cell Biochem 119:4644-4655 |
| Engelhard, Victor H; Rodriguez, Anthony B; Mauldin, Ileana S et al. (2018) Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity. J Immunol 200:432-442 |
| Martins, André L; Walavalkar, Ninad M; Anderson, Warren D et al. (2018) Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions. Nucleic Acids Res 46:e9 |
| Michaels, Alex D; Newhook, Timothy E; Adair, Sara J et al. (2018) CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer. Clin Cancer Res 24:1415-1425 |
| Shi, Lei; Li, Kang; Guo, Yizhan et al. (2018) Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer. Proc Natl Acad Sci U S A 115:11808-11813 |
| Yang, Jun; LeBlanc, Francis R; Dighe, Shubha A et al. (2018) TRAIL mediates and sustains constitutive NF-?B activation in LGL leukemia. Blood 131:2803-2815 |
| Kulling, Paige M; Olson, Kristine C; Hamele, Cait E et al. (2018) Dysregulation of the IFN-?-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLoS One 13:e0193429 |
| Grant, Margaret J; Loftus, Matthew S; Stoja, Aiola P et al. (2018) Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tether. Proc Natl Acad Sci U S A 115:4992-4997 |
| Knapp, Kiley A; Pires, Eusebio S; Adair, Sara J et al. (2018) Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer. Oncotarget 9:8972-8984 |
| Kedzierska, Katarzyna Z; Gerber, Livia; Cagnazzi, Daniele et al. (2018) SONiCS: PCR stutter noise correction in genome-scale microsatellites. Bioinformatics 34:4115-4117 |
Showing the most recent 10 out of 539 publications
