The goal of the Cold Spring Laboratory Cancer Center is to promote inter-disciplinary and high quality basic research on different aspects of cancer. The Cancer Center is organized into three established research programs. The Gene Expression Program is multi-disciplinary is organized into three established research programs. The Gene Expression Program is multi-disciplinary and focuses on the regulation of gene expression in normal and cancer cells and HIV infection in AIDS. The Cell Biology Program focuses on signal transduction, cell division cycle control and cell architecture and structure in normal cancer cells. The Cancer Genetics Program focuses on understanding the genetic basis of cancer, cancer progress in vivo and develops biochemical and genetic tools that will enhance our capacity, cancer progression in vivo and develops biochemical and genetic tools that will enhance our capacity to treat and diagnose the disease. The Center has a thirteen Shared Resources Bioinformatics, Flow Cytometry, Gene Targeting and Transgenic Mouse, Genomics, Graphic Arts, Instrumentation, Microscopy, Monoclonal Antibody, Nucleic Acid Chemistry, Protein Chemistry, and Radiation. Developmental funds provide support for new initiative and recruiting. These Programs and Resources are organized into a coordinated Center with a clearly defined administrative structure that promotes scientific excellence in cancer research.
| Kumar, Vijay; Rosenbaum, Julie; Wang, Zihua et al. (2018) Partial bisulfite conversion for unique template sequencing. Nucleic Acids Res 46:e10 |
| Lee, Je H (2018) Tracing single-cell histories. Science 359:521-522 |
| Alexander, Joan; Kendall, Jude; McIndoo, Jean et al. (2018) Utility of Single-Cell Genomics in Diagnostic Evaluation of Prostate Cancer. Cancer Res 78:348-358 |
| Huang, Yu-Han; Klingbeil, Olaf; He, Xue-Yan et al. (2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev 32:915-928 |
| Tiriac, Hervé; Belleau, Pascal; Engle, Dannielle D et al. (2018) Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov 8:1112-1129 |
| Naguib, Adam; Mathew, Grinu; Reczek, Colleen R et al. (2018) Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. Cell Rep 23:58-67 |
| Forcier, Talitha L; Ayaz, Andalus; Gill, Manraj S et al. (2018) Measuring cis-regulatory energetics in living cells using allelic manifolds. Elife 7: |
| Bhagwat, Anand S; Lu, Bin; Vakoc, Christopher R (2018) Enhancer dysfunction in leukemia. Blood 131:1795-1804 |
| Aberle, M R; Burkhart, R A; Tiriac, H et al. (2018) Patient-derived organoid models help define personalized management of gastrointestinal cancer. Br J Surg 105:e48-e60 |
| Chen, Wei-Chia; Tareen, Ammar; Kinney, Justin B (2018) Density Estimation on Small Data Sets. Phys Rev Lett 121:160605 |
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