The University of Michigan Comprehensive Cancer Center (UMCCC) is one of the nation's premiere multidisciplinary cancer research programs, with a long Institutional tradition of excellence in patient and population-based research. The Patient and Population Core is a new cancer center core resource that has been developed as a result of UMCCC's strategic planning to meet key needs of cancer center researchers identified through a strategic planning process. Programs in cancer prevention and control, clinical research, and basic science all require enhanced access to annotated patient and population data with accompanying DNA samples In order to continue the cancer center's mission and commitment to achieve innovative research in personalized cancer prevention, diagnosis and treatment. The Patient and Population Core is a resource that collects, catalogs, and stores DNA samples together with highly annotated, linked clinical and epidemiologic Information from cancer patients and representative controls without cancer. Building upon an already established cancer center infrastructure and health-system wide institutional commitment to biobanking, the Patient and Population Core takes advantage of the combined resources of the Michigan Institute for Clinical Health Research (MICHR) Biorepository and the Michigan Clinical Research Unit (MCRU) to provide cancer-specific resources to members of the cancer center, This resource will facilitate environmental, susceptibility, prognostic, and mechanistic studies to be conducted by researchers from various disciplines within the cancer center, as well as provide opportunities for pilot studies and resources for successful grant submissions for translational and molecular epidemiologic research studies, by linking specimen data with questionnaire and medical record data. The overall goal of this core is to further empower our investigators, promote resource sharing, and maximize the value of data and DNA sample collection for research participants, investigators, UMCCC members, and our funding agencies. Since its inception in April 2010, DNA samples and data from 3,910 patients have been established within the Patient and Population Core repository, and 7 cancer center members have accessed DNA samples and data. CCSG funding comprises 36% of the proposed core budget, with the remaining support from charge-backs at rates determined by institution-wide metrics and other institutional support.
The Patient and Population Core is dedicated to providing a biolibrary for cancer researchers to understand the causes and cures of cancer. By creating an exceptional resource that contains both data and biosamples of patients with cancer and healthy individuals at risk of cancer, the Patient and Population Core directly contributes to the public health mission of the University of Michigan Comprehensive Cancer Center.
| Katz, Steven J; Ward, Kevin C; Hamilton, Ann S et al. (2018) Gaps in Receipt of Clinically Indicated Genetic Counseling After Diagnosis of Breast Cancer. J Clin Oncol 36:1218-1224 |
| Ulintz, Peter J; Greenson, Joel K; Wu, Rong et al. (2018) Lymph Node Metastases in Colon Cancer Are Polyclonal. Clin Cancer Res 24:2214-2224 |
| Khoriaty, Rami; Hesketh, Geoffrey G; Bernard, Amélie et al. (2018) Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A 115:E7748-E7757 |
| Xu, Shilin; Aguilar, Angelo; Xu, Tianfeng et al. (2018) Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl 57:1601-1605 |
| Crespo, Joel; Wu, Ke; Li, Wei et al. (2018) Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol 201:814-820 |
| Qin, Tingting; Zhang, Yanxiao; Zarins, Katie R et al. (2018) Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort. Sci Rep 8:11458 |
| Hawley, Sarah T; Li, Yun; An, Lawrence C et al. (2018) Improving Breast Cancer Surgical Treatment Decision Making: The iCanDecide Randomized Clinical Trial. J Clin Oncol 36:659-666 |
| Salami, Simpa S; Hovelson, Daniel H; Kaplan, Jeremy B et al. (2018) Transcriptomic heterogeneity in multifocal prostate cancer. JCI Insight 3: |
| Manohar, Poorni M; Beesley, Lauren J; Bellile, Emily L et al. (2018) Prognostic Value of FDG-PET/CT Metabolic Parameters in Metastatic Radioiodine-Refractory Differentiated Thyroid Cancer. Clin Nucl Med 43:641-647 |
| Eberl, Markus; Mangelberger, Doris; Swanson, Jacob B et al. (2018) Tumor Architecture and Notch Signaling Modulate Drug Response in Basal Cell Carcinoma. Cancer Cell 33:229-243.e4 |
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