(CANCER EPIDEMIOLOGY AND PREVENTION) The Cancer Epidemiology and Prevention (CEP) Program is a group of interdisciplinary population health and medical scientists that conduct research to elucidate environmental, lifestyle and genetic causes of cancer, and develop and test strategies and interventions to prevent and reduce the risk of cancer. CEP program members also focus on developing statistical and mathematical approaches to advance cancer research. The program is comprised of 29 members from 17 different departments and three schools with total annual direct research support of $5.8 million - of which $4.7 million (81%) is from the NCI. Members are highly productive, with 533 publications during the project period, of which 17.4% are intra-programmatic and 35.3% are inter- programmatic. Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with researchers in the other University of Michigan Comprehensive Cancer Center programs. The CEP program has three main specific aims: 1) Elucidate risk and protective factors for common and high-mortality cancers, with a focus on lifestyle, environmental and molecular exposures; 2) Discover and implement primary, secondary and tertiary prevention strategies incorporating environmental and personal exposures and state-of- the-art genomic, proteomic, metabolomic, and imaging biotechnologies; and 3) Develop and operationalize novel biostatistical and analytic methods for big data and personalized prevention and screening.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA046592-29
Application #
9488245
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Feng, Mary; Suresh, Krithika; Schipper, Matthew J et al. (2018) Individualized Adaptive Stereotactic Body Radiotherapy for Liver Tumors in Patients at High Risk for Liver Damage: A Phase 2 Clinical Trial. JAMA Oncol 4:40-47
Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
El Kadi, Najwa; Wang, Luo; Davis, April et al. (2018) The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer. Cancer Res 78:6728-6735
Namkoong, Sim; Ho, Allison; Woo, Yu Mi et al. (2018) Systematic Characterization of Stress-Induced RNA Granulation. Mol Cell 70:175-187.e8
Thomas, Tina T; Chukkapalli, Sahiti; Van Noord, Raelene A et al. (2018) Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts. J Vis Exp :
Eisenberg, Marisa C; Campredon, Lora P; Brouwer, Andrew F et al. (2018) Dynamics and Determinants of HPV Infection: The Michigan HPV and Oropharyngeal Cancer (M-HOC) Study. BMJ Open 8:e021618
Boonstra, Philip S; Barbaro, Ryan P (2018) Incorporating historical models with adaptive Bayesian updates. Biostatistics :
Johnson, Allison M; Roach, James P; Hu, Anna et al. (2018) Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure. FASEB J 32:2615-2629
Feinberg, Tamar Y; Zheng, Huarui; Liu, Rui et al. (2018) Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs. Dev Cell 47:145-160.e6
Hrycaj, Steven M; Marty-Santos, Leilani; Cebrian, Cristina et al. (2018) Hox5 genes direct elastin network formation during alveologenesis by regulating myofibroblast adhesion. Proc Natl Acad Sci U S A 115:E10605-E10614

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