(CANCER EPIDEMIOLOGY AND PREVENTION) The Cancer Epidemiology and Prevention (CEP) Program is a group of interdisciplinary population health and medical scientists that conduct research to elucidate environmental, lifestyle and genetic causes of cancer, and develop and test strategies and interventions to prevent and reduce the risk of cancer. CEP program members also focus on developing statistical and mathematical approaches to advance cancer research. The program is comprised of 29 members from 17 different departments and three schools with total annual direct research support of $5.8 million - of which $4.7 million (81%) is from the NCI. Members are highly productive, with 533 publications during the project period, of which 17.4% are intra-programmatic and 35.3% are inter- programmatic. Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with researchers in the other University of Michigan Comprehensive Cancer Center programs. The CEP program has three main specific aims: 1) Elucidate risk and protective factors for common and high-mortality cancers, with a focus on lifestyle, environmental and molecular exposures; 2) Discover and implement primary, secondary and tertiary prevention strategies incorporating environmental and personal exposures and state-of- the-art genomic, proteomic, metabolomic, and imaging biotechnologies; and 3) Develop and operationalize novel biostatistical and analytic methods for big data and personalized prevention and screening.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA046592-31
Application #
9993333
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
31
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Xiong, Xiufang; Liu, Xia; Li, Haomin et al. (2018) Ribosomal protein S27-like regulates autophagy via the ?-TrCP-DEPTOR-mTORC1 axis. Cell Death Dis 9:1131
Menghrajani, Kamal; Boonstra, Philip S; Mercer, Jessica A et al. (2018) Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis. Leuk Lymphoma :1-7
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Nanba, Kazutaka; Omata, Kei; Else, Tobias et al. (2018) Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans. J Clin Endocrinol Metab 103:3869-3876
Maust, Joel D; Frankowski-McGregor, Christy L; Bankhead 3rd, Armand et al. (2018) Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. Mol Cancer Ther 17:2495-2506
Hoban, Connor W; Beesley, Lauren J; Bellile, Emily L et al. (2018) Individualized outcome prognostication for patients with laryngeal cancer. Cancer 124:706-716
Valenciaga, Anisley; Saji, Motoyasu; Yu, Lianbo et al. (2018) Transcriptional targeting of oncogene addiction in medullary thyroid cancer. JCI Insight 3:
Arthur, Anna E; Goss, Amy M; Demark-Wahnefried, Wendy et al. (2018) Higher carbohydrate intake is associated with increased risk of all-cause and disease-specific mortality in head and neck cancer patients: results from a prospective cohort study. Int J Cancer 143:1105-1113
Anwar, Talha; Arellano-Garcia, Caroline; Ropa, James et al. (2018) p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis. Nat Commun 9:2801
Akkina, Sarah R; Kim, Roderick Y; Stucken, Chaz L et al. (2018) Is There a Difference in Staging and Treatment of Head and Neck Squamous Cell Tumors Between Tertiary Care and Community-Based Institutions? Laryngoscope Investig Otolaryngol 3:290-295

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