) The Biological Therapeutics Program brings together clinical and basic investigators interested in immunotherapy and biological therapy of cancer. The Program has the following five goals: (a) to implement clinical investigations of biological therapies in patients with cancer; (b) to foster and facilitate interactions among the Program members; (c) to foster appropriate laboratory studies for support and biologic insights from the clinical trials; (d) to maintain a vigorous translational research program; and (e) to establish and promote a strong training program in biological therapeutics. Under the leadership of Drs. Lotze and Whiteside, the Program has been successfully accomplishing these objectives. Ten new clinical trials including vaccine administration, cytokines, dendritic cells or genetically modified cells have been initiated in the past year. Supported by five current program project grants, the translational research program has had significant accomplishments and continues providing a strong conceptual basis for novel clinical trials. Interactions among Program members are extensive, and collaborations are strengthened by joint grant applications, scientific meetings, an annual retreat and our newsletter """"""""In Vivo Veritas"""""""". The IML and Cellular Products Laboratory provide outstanding support for the Program's clinical trials. A training grant in Biological Therapeutics was funded earlier this year, and new clinical fellows are starting their rotations. Overall, the Program has created a stimulating environment for colleagues working in the field of biotherapy, and it is recognized both nationally and internationally for its accomplishments, innovative approaches, and effective translation of laboratory insights into clinical therapeutic applications.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA047904-12
Application #
6212117
Study Section
Subcommittee G - Education (NCI)
Project Start
1988-08-01
Project End
2004-07-30
Budget Start
Budget End
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Yockey, Laura J; Jurado, Kellie A; Arora, Nitin et al. (2018) Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol 3:
Chen, Jingci; Nagle, Alison M; Wang, Yu-Fen et al. (2018) Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. J Biol Chem 293:3700-3709
Qin, Ye; Vasilatos, Shauna N; Chen, Lin et al. (2018) Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Oncogene :
Steinman, Justin; Epperly, Michael; Hou, Wen et al. (2018) Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res 189:68-83
Evdokimova, Viktoria N; Gandhi, Manoj; Nikitski, Alyaksandr V et al. (2018) Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements. Oncotarget 9:13612-13622
Bissel, Stephanie J; Gurnsey, Kate; Jedema, Hank P et al. (2018) Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. Retrovirology 15:17
Knickelbein, Kyle; Tong, Jingshan; Chen, Dongshi et al. (2018) Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene 37:4599-4610
Diaz-Perez, Julio A; Killeen, Meaghan E; Yang, Yin et al. (2018) Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis. J Invest Dermatol 138:2595-2605
Ancevski Hunter, Katerina; Socinski, Mark A; Villaruz, Liza C (2018) PD-L1 Testing in Guiding Patient Selection for PD-1/PD-L1 Inhibitor Therapy in Lung Cancer. Mol Diagn Ther 22:1-10
Luu, Thehang; Kim, Kyu-Pyo; Blanchard, Suzette et al. (2018) Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer. Breast Cancer Res Treat 167:469-478

Showing the most recent 10 out of 1187 publications