Abstract

The Basic Genomics and Proteomics Facility(BGPF) is a newly proposed core to provide state-of-the-art genomic and proteomic technologies to UPCI investigators for basic research applications. The services encompass a wide range of technologies including cytogenetics, DNA sequencing, DNA and RNA isolation, Serial Analysis of Gene Expression (SAGE) library production, SNP genotyping, STRP genotyping, Array analysis (Affymetrix, CodeLink, and custom arrays), Quantitative RT-PCR, Difference Gel Electrophoresis, Ciphergen Proteinchip Profiling, Protein identification and sequencing.
The specific aims of the BGPF are: 1. To provide access to genomics technologies for basic cancer research and help investigators determine which technologies are most applicable for their research. 2. To provide access to proteomics technologies for basic cancer research and help investigators determine which technologies are most applicable for their research. 3. To provide access to tools and expertise in genomic and proteomic data analysis and interpretation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA047904-18
Application #
7111836
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
18
Fiscal Year
2005
Total Cost
$124,564
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Li, Changfeng; Zhang, Ying; Cheng, Xing et al. (2018) PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism. Dev Cell 46:441-455.e8
Welty, Starr; Teng, Yaqun; Liang, Zhuobin et al. (2018) RAD52 is required for RNA-templated recombination repair in post-mitotic neurons. J Biol Chem 293:1353-1362
Li, Xiang; George, Subin M; Vernetti, Lawrence et al. (2018) A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab Chip 18:2614-2631
Singh, Renu; Mehrotra, Shailly; Gopalakrishnan, Mathangi et al. (2018) Population pharmacokinetics and exposure-response assessment of veliparib co-administered with temozolomide in patients with myeloid leukemias. Cancer Chemother Pharmacol :
Nehmeh, Sadek A; Schwartz, Jazmin; Grkovski, Milan et al. (2018) Inter-operator variability in compartmental kinetic analysis of 18F-fluoromisonidazole dynamic PET. Clin Imaging 49:121-127
Woodcock, Chen-Shan Chen; Huang, Yi; Woodcock, Steven R et al. (2018) Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth. J Biol Chem 293:1120-1137
Posluszny, Donna M; Bovbjerg, Dana H; Syrjala, Karen L et al. (2018) Correlates of anxiety and depression symptoms among patients and their family caregivers prior to allogeneic hematopoietic cell transplant for hematological malignancies. Support Care Cancer :
Pulopulos, Matias M; Kozusznik, Malgorzata W (2018) The moderating role of meaning in life in the relationship between perceived stress and diurnal cortisol. Stress 21:203-210
Wang, Zehua; Yang, Bo; Zhang, Min et al. (2018) lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell 33:706-720.e9
Volonte, Daniela; Vyas, Avani R; Chen, Chen et al. (2018) Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence. J Biol Chem 293:1794-1809

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