Abstract

A primary goal of the clinical trials efforts of UPCI is to design, implement and analyze innovative, investigator-initiated phase I and II clinical trials. The dcvelopment, initiation, implementation and completion of UPCI investigational studies receive substantial and essential support from UPCI Clinical Research Services (CRS). The assigned clinical research coordinators are involved in study design and implementation, design of study schema, forms design, patient education and compliance, collection, handling and shipping of specimens, collection and entry of data and keeping the principal investigator informed of all patient and research issues. UPCI has made noteworthy advances, in innovative pilot and phase I studies in the last 5 years, in several programs including Molecular Therapeutics and Drug Discovery, Biological Therapeutics, Prostate and Urologic Cancers, Head and Neck Cancer, Immunology, and breast cancer. The PSRC is utilized by UPCI members from all of these and other programs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA047904-19
Application #
7279245
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
19
Fiscal Year
2006
Total Cost
$93,382
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Ander, Stephanie E; Rudzki, Elizabeth N; Arora, Nitin et al. (2018) Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines. MBio 9:
Hartmaier, R J; Trabucco, S E; Priedigkeit, N et al. (2018) Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer. Ann Oncol 29:872-880
Palliyaguru, Dushani L; Yuan, Jian-Min; Kensler, Thomas W et al. (2018) Isothiocyanates: Translating the Power of Plants to People. Mol Nutr Food Res 62:e1700965
Yoon, Joo Heung; Nouraie, Mehdi; Chen, Xiaoping et al. (2018) Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease - analysis of institutional and population data. Respir Res 19:195
Nikiforova, Marina N; Mercurio, Stephanie; Wald, Abigail I et al. (2018) Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules. Cancer 124:1682-1690
Steel, Jennifer L; Terhorst, Lauren; Collins, Kevin P et al. (2018) Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer. Psychosom Med 80:483-491
Luthra, Soumya; Chandran, Uma; Diergaarde, Brenda et al. (2018) Expression of reactive species related genes is associated with patient survival in luminal B breast cancer. Free Radic Biol Med 120:170-180
Saydmohammed, Manush; Tsang, Michael (2018) High-Throughput Automated Chemical Screens in Zebrafish. Methods Mol Biol 1683:383-393
Steinman, Justin; Epperly, Michael; Hou, Wen et al. (2018) Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res 189:68-83
Yockey, Laura J; Jurado, Kellie A; Arora, Nitin et al. (2018) Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol 3:

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