Researchers cannot provide all of the necessary elements to support clinical and research based information intensive studies in a cost effective and efficient manner, The spectrum of needs, from those of a basic scientist to those of an outcomes-based clinical researcher requires a robust architecture of software, hardware and information technology professionals to develop and maintain these tools. The cost of equipment, the rapid pace of technology development and the specialized expertise (e.g. human computer interaction/ethnography expertise, information scientists, data managers, quality control specialists, honest brokers, HIPAA compliance specialists, bioinformatics analyst, network/storage specialists, etc...) required to properly manage the informatics needs of the UPCI are not possible without high quality and efficient Cancer Informatics Services (CIS). It is therefore critical that this resource be well supported and integrated into UPCI's research mission. The CIS at UPCI is composed of the following tightly integrated services: 1) Clinical Trials Management Application - supporting all of the clinical trials of UPCI 2) Tissue Banking Information System - supporting pathologic annotation and inventory control of the biospecimen (tissue, blood, serum and body fluids) requests of UPCI researchers 3) Registry Research Information Services - supporting all of the clinical and outcomes annotation of patients in clinical trials and who contribute their cancer tissues to the tissue bank 4) Honest Broker Services - an important new component for HIPAA compliant research information services 5) Organ Specific Databases - a data mining tool for organ site specific programs that facilitates HIPAA compliant and de-identified access to patient tumor stage, grade, etc, as well as study' cohort availability 6) Storage, Archival and Network Services - fulfill the needs of the UPCI for a robust network and storage solution for clinical trials, tissue banking, imaging, genomic and proteomic data archiving which is actively maintained and backed up. UPCI will be increasingly reliant on developing robust research information services to more effectively support the translation of innovation from the laboratory to the bedside and to utilize critical clinical and outcomes data in the clinic to guide discovery at the bench. This is the key focus of the Cancer Informatics Services at the UPCI.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA047904-19
Application #
7279250
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
19
Fiscal Year
2006
Total Cost
$196,538
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Wang, Yue; Wang, Zehua; Xu, Jieni et al. (2018) Systematic identification of non-coding pharmacogenomic landscape in cancer. Nat Commun 9:3192
Lee, Young-Sun; Lee, Dae-Hee; Choudry, Haroon A et al. (2018) Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis. Mol Cancer Res 16:1073-1076
Tong, Jingshan; Zheng, Xingnan; Tan, Xiao et al. (2018) Mcl-1 Phosphorylation without Degradation Mediates Sensitivity to HDAC Inhibitors by Liberating BH3-Only Proteins. Cancer Res 78:4704-4715
Menk, Ashley V; Scharping, Nicole E; Rivadeneira, Dayana B et al. (2018) 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med 215:1091-1100
Caves, Elizabeth A; Cook, Sarah A; Lee, Nara et al. (2018) Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere 3:
Saydmohammed, Manush; Vollmer, Laura L; Onuoha, Ezenwa O et al. (2018) A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules 23:
Gough, Albert; Shun, Tong Ying; Taylor, D Lansing et al. (2018) Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies. Methods Mol Biol 1745:25-46
Fletcher, Rochelle; Wang, Yi-Jun; Schoen, Robert E et al. (2018) Colorectal cancer prevention: Immune modulation taking the stage. Biochim Biophys Acta Rev Cancer 1869:138-148
Li, Xiang; George, Subin M; Vernetti, Lawrence et al. (2018) A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Lab Chip 18:2614-2631
Singh, Renu; Mehrotra, Shailly; Gopalakrishnan, Mathangi et al. (2018) Population pharmacokinetics and exposure-response assessment of veliparib co-administered with temozolomide in patients with myeloid leukemias. Cancer Chemother Pharmacol :

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