The new Radiation Research and Translational Biology, (RRTB) program integrates elements from threeprior Kimmel Cancer Center programs: Structural Biology and Bioinformatics Program, DevelopmentalTherapeutics Program, and Hematological Malignancies and Stem Cell Transplantation Program. Thisrestructuring was undertaken to leverage key strengths of clinical research at the KCC in RadiationOncology, Hematological Malignancies, and Stem Cell Transplantation to create a program that conductsbench to bedside research with sustained return of clinical data to the bench in the form of reversetranslation. The central themes of the new program include angiogenesis, stem cell function andmicroenvironmental mediators of the radiation response. The RRTB is an interdisciplinary programcomprised of basic, translational and clinical investigators from eight departments and multiple areas ofactive investigation, interest and expertise. Their work is supported by $18 million in peer-reviewed funding($16.0 M from NCI). The total number of publications of Program members is 940 of which 16% areIntraprogrammmatic and 14% are Interprogrammatic. The program is a multidisciplinary effort with the goalof defining fundamental mechanisms and targets in radiation research and translational biology, which canfacilitate innovations in treating cancer in patients. The specific goals of the RRTB Program are: (1) Defineand characterize molecular targets for ionizing radiation. (2) Hypoxia and Angiogenesis: Elucidatemechanisms regulating HIF, integrate angiogenesis inhibitors with ionizing radiation and preclinical andclinical imaging of angiogenesis. (3) Study normal tissue injury/genotoxic stress. (4) Understand radiationtarget elucidation and modification and (5) Discover and translate diagnostic and therapeutic innovationsdeveloped in the laboratories of KCC members to clinical practice. This new program has generated newcollaborations within the program and fresh research directions with other research programs in the cancercenter.
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