Abstract

SMALL ANIMAL IMAGING SHARED RESOURCEThe Small Animal Imaging Shared Resource provides state-of-the-art in vivo molecular imaging capabilitiesto the investigators of the Kimmel Cancer Center. It was established under the direction of Dr. MathewThakur in April 2004 supported, to date, by the Thomas Jefferson University and the Department ofRadiology. This resource provides non-invasive small animal imaging, with PET, SPECT, CT and ultrasound.These modalities offer innovative basic, as well as pre-clinical translational, research capabilities for studyingpatho-physiology and genesis of cancer. In addition to providing comprehensive imaging services theexpertise exists to a) custom synthesize probes specific for targeted bio-markers; b) develop new imagegeneration and analysis techniques; and c) train cancer investigators to harness the strengths of molecularimaging. The facility is supported by three AALAC accredited animal houses and two veterinarian staffmembers. Thus far this shared resource has supported fifteen federally funded investigations related tooncology and enhanced productivity as depicted by several publications in peer-reviewed journals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA056036-09
Application #
7712919
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-09-05
Project End
2013-05-31
Budget Start
2008-09-05
Budget End
2009-05-31
Support Year
9
Fiscal Year
2008
Total Cost
$61,674
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Type
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara et al. (2018) Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep 23:3127-3136
Lu, Huimin; Bowler, Nicholas; Harshyne, Larry A et al. (2018) Exosomal ?v?6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol 70:20-35
Lapadula, Dominic; Farias, Eduardo; Randolph, Clinita E et al. (2018) Effects of Oncogenic G?q and G?11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res :
Vite, Alexia; Zhang, Caimei; Yi, Roslyn et al. (2018) ?-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145:
McNair, Christopher; Xu, Kexin; Mandigo, Amy C et al. (2018) Differential impact of RB status on E2F1 reprogramming in human cancer. J Clin Invest 128:341-358
Garcia, Samantha A; Lebrun, Aurore; Kean, Rhonda B et al. (2018) Clearance of attenuated rabies virus from brain tissues is required for long-term protection against CNS challenge with a pathogenic variant. J Neurovirol 24:606-615
Vido, Michael J; Le, Kaitlyn; Hartsough, Edward J et al. (2018) BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. Cell Rep 25:1501-1510.e3
Brody, Jonathan R; Dixon, Dan A (2018) Complex HuR function in pancreatic cancer cells. Wiley Interdiscip Rev RNA 9:e1469
Liao, Lili; Liu, Zongzhi Z; Langbein, Lauren et al. (2018) Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. Elife 7:
Heeke, Arielle L; Pishvaian, Michael J; Lynce, Filipa et al. (2018) Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types. JCO Precis Oncol 2018:

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