X-RAY CRYSTALLOGRAPHY SHARED RESOURCEThe X-ray Crystallography shared resource provides KCC investigators the ability to obtain structuralinformation directly relevant to their research interests. This includes the determination of de novo structures,structural consequences of point mutations, co-crystallization with small molecules including inhibitors andpotential therapeutics, and multicomponent systems including proteins, DNA and/or RNA. Although structuredetermination is a highly specialized, labor-intensive endeavor, the information obtained from theseinvestigations frequently addresses seemingly disparate biochemical data and invariably improves futureresearch efforts.Significant progress has been made to improve access to the facility for the KCC community. For instance, aliquid handling robot now tests for crystallization feasibility with significantly less material and personal effort,making preliminary screening experiments cost effective. This has encouraged a number of KCC members toconsider employing structural biology in their program. The Department of Biochemistry and Molecular Biologyrecognizes the significance of structural biology to the university, and has made an additional hire in structuralbiology at the assistant professor level. With the increase of users and the new hire, we anticipate that anumber of new structures will be forthcoming, most with immediate relevance to molecular origin of cancer.
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