For the next 5 year cycle of the Cancer Center Support Grant, the Kimmel Cancer Center is requesting Developmental Funds to foster collaborative research projects among KCC consortium cancer center members. During the past grant cycle, no developmental funds were available from the CCSG. However, through a combination of philanthropy, ARRA funding, and an American Cancer Society Institutional Research Grant, 60 projects were funded. These funds are a critical source of flexible funding for the KCC, and provide a vital source of support for new research opportunities through pilot project funding. In addition funds are requested to facilitate recruitment of new faculty. Center-wide recruitment needs have been identified in several areas: Translational Breast Cancer Research (BBC), Radiation Research (RRTB), Epigenetics in Cancer (MBG) and Molecular Epidemiology (Gl). The KCC Basic Science Advisory Committee will play a central role in determining which pilot projects requests will be funded. Therefore, it is important to note that the Committee which will be making the decision will include faculty from all the consortium partners (TJU, LIMR, Drexel), and faculty from all the consortium partners will be eligible to apply for pilot project funding. Members of the developing program in Population Science will be eligible to apply for pilot project funding under a somewhat altered process.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-18
Application #
9282724
Study Section
Subcommittee A - Cancer Centers (NCI-A)
Project Start
2017-06-01
Project End
2018-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
18
Fiscal Year
2017
Total Cost
$64,174
Indirect Cost
$22,301
Name
Thomas Jefferson University
Department
Type
Domestic Higher Education
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Magee, Michael S; Abraham, Tara S; Baybutt, Trevor R et al. (2018) Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer Immunol Res 6:509-516
Chervoneva, Inna; Freydin, Boris; Hyslop, Terry et al. (2018) Modeling qRT-PCR dynamics with application to cancer biomarker quantification. Stat Methods Med Res 27:2581-2595
Capparelli, Claudia; Purwin, Timothy J; Heilman, Shea A et al. (2018) ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma. Cancer Res 78:5680-5693
Nevler, Avinoam; Muller, Alexander J; Cozzitorto, Joseph A et al. (2018) A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2. J Am Coll Surg 226:596-603
Peng, Weidan; Furuuchi, Narumi; Aslanukova, Ludmila et al. (2018) Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development. Mol Cell Biol 38:
Waldman, Scott A; Camilleri, Michael (2018) Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. Gut 67:1543-1552
Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara et al. (2018) Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep 23:3127-3136
Lu, Huimin; Bowler, Nicholas; Harshyne, Larry A et al. (2018) Exosomal ?v?6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol 70:20-35
Lapadula, Dominic; Farias, Eduardo; Randolph, Clinita E et al. (2018) Effects of Oncogenic G?q and G?11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res :
Vite, Alexia; Zhang, Caimei; Yi, Roslyn et al. (2018) ?-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145:

Showing the most recent 10 out of 807 publications