The Robert H. Lurie Comprehensive Cancer Center Mouse Phenotyping Core Facility provides comprehensive gross and histopathologic assessment of murine phenotypes, histological evaluation of tissue derived from animal tumor models, and training sessions for investigators to learn to detect gross anomalies in mice, harvest tissue from various organ systems, and to perform immunohistochemical or special stains on tissue sections. This Core Facility was developed to fulfill a need by the investigative community to accurately analyze their new murine models and to enhance the ability to extract meaningful phenotypic information to guide future investigations. Murine tissue has histological characteristics distinct from human tissue;therefore, assessment under the microscope requires pathologists with experience in murine histology. Moreover, tissue harvesting, processing, and sectioning demands precision, especially in the case of embryonic lethal phenotypes. The Core Facility is directed by a perinatal pathologist with more than fifteen years of experience in animal tissue assessment, immunohistochemical analyses, and pathology. Her extensive background in developmental anomalies allows for accurate assessment of embryonic lethal phenotypes and for establishing the proximate cause of the demise. Other team members of this facility include a second perinatal pathologist, a molecular biologist, and a certified histotechnologist. Together, this team provides invaluable expertise to investigators by offering insight into phenotypes of newly developed murine models, by providing training sessions in tissue harvesting and analysis, and by assisting with performance and grading of immunohistochemical studies. This comprehensive approach to phenotyping viable and embryonic lethal models has the potential to discover new target organ systems and signaling partners for molecules and to identify innovative model systems to study cancer biology for the scientific community.
| Lewis, Phillip L; Green, Richard M; Shah, Ramille N (2018) 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression. Acta Biomater 69:63-70 |
| Ugolkov, Andrey V; Bondarenko, Gennadiy I; Dubrovskyi, Oleksii et al. (2018) 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs 29:717-724 |
| Chen, Charlotte H; Palmer, Liam C; Stupp, Samuel I (2018) Self-Repair of Structure and Bioactivity in a Supramolecular Nanostructure. Nano Lett 18:6832-6841 |
| Volk, Andrew; Liang, Kaiwei; Suraneni, Praveen et al. (2018) A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis. Cancer Cell 34:707-723.e7 |
| Graves, Stephen; Seagle, Brandon-Luke L; Kocherginsky, Masha et al. (2018) Scholarship Support for Veterans Enrolling in MD, JD, and MBA Programs. JAMA 320:1197-1198 |
| Du, Jingshan S; Chen, Peng-Cheng; Meckes, Brian et al. (2018) Windowless Observation of Evaporation-Induced Coarsening of Au-Pt Nanoparticles in Polymer Nanoreactors. J Am Chem Soc 140:7213-7221 |
| Gao, Ruoqi; Piguel, Nicolas H; Melendez-Zaidi, Alexandria E et al. (2018) CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Mol Psychiatry 23:1832-1850 |
| Greene, Jacqueline J; McClendon, Mark T; Stephanopoulos, Nicholas et al. (2018) Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair. J Tissue Eng Regen Med 12:1389-1401 |
| Stack, Trevor; Vahabikashi, Amir; Johnson, Mark et al. (2018) Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles. J Biomed Mater Res A 106:1771-1779 |
| Blair, Kris M; Mears, Kevin S; Taylor, Jennifer A et al. (2018) The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton. Mol Microbiol 110:114-127 |
Showing the most recent 10 out of 1972 publications
