The Cancer Informatics Core is comprised of informatics faculty and staff who are focused on providing informatics services and necessary computational infrastructure for the diverse informatics needs of Cancer Center members in the Robert H. Lurie Comprehensive Cancer Center. The Core works closely with RHLCCC governance committees to promulgate standards, provide advice and guidance, optimize systems and minimize redundancy through continued integration of data, databases, applications, software and computational infrastructure that is necessary to support cancer translational research. Since the last competitive renewal, the Core has established a scalable high performance cyber-infrastructure equipped with >200 TB of tiered storage and a virtualized data center to meet the data and computational needs of Cancer Center members. The Core also provides access and training for Cancer Center members on the 7000 core Northwestern Quest cluster for projects requiring high performance computing. During the past five years, the Core has met its primary goals of providing the necessary computational infrastructure for managing clinical trials with the Clinical Research Office, storage for microarray and next generation sequencing. The core has provided the necessary oversight, project management, and software development expertise to deliver data management and reporting applications for prostate cancer and breast cancer repositories. The core has also worked closely with the RHLCCC neuro-oncology investigators to deliver innovative patient-facing intake and assessment applications that are coupled to clinical data available through the Enterprise Data Warehouse with molecular data coming from biospecimens, including gene expression, copy number, and methylation data. We have also provided sophisticated gene expression analysis, pathway enrichment analysis, and methylation data analysis including visualization methods for more than 70 cancer center members and 160 projects during the past five years. In addition to providing these genomic analysis services to our cancer center members, we have released the tools developed for these projects as open source bioconductor packages [lumi, GeneAnswers, ChlPpeakAnno, MassSpecWavelet). The core has also developed, in conjunction with the Northwestern University Biomedical Informatics Center (part ofthe Northwestern CTSA) a number of web-based clinical research software modules that have been released as open source tools (Patient Study Calendar, Registar, eNOTIS, Surveyor). In addition, the core has developed and released tools for scientific network analysis (LatticeGrid) and competition management (NUCATS Assist). The Core will continue to support and extend these activities. We anticipate that during the next five year there will be additional member-driven demand in the area of next generation sequencing, high performance computing, and FISMA compliant computing.
The overall goal of the Cancer Informatics Core facility is to provide RHLCCC investigators with genomic analysis tools, data management services, and cyber-infrastructure to answer cancer research questions. To accelerate cancer research in the RHLCCC, the Cancer Informatics Core works closely with cancer investigators and RHLCCC cores including the Clinical Research Office, the Biostatistics Core Facility, Cell Imaging, Pathology Core, Outcomes Measure and Survey Core, and the Flow Cytometry Core.
| Lewis, Phillip L; Green, Richard M; Shah, Ramille N (2018) 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression. Acta Biomater 69:63-70 |
| Ugolkov, Andrey V; Bondarenko, Gennadiy I; Dubrovskyi, Oleksii et al. (2018) 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs 29:717-724 |
| Chen, Charlotte H; Palmer, Liam C; Stupp, Samuel I (2018) Self-Repair of Structure and Bioactivity in a Supramolecular Nanostructure. Nano Lett 18:6832-6841 |
| Volk, Andrew; Liang, Kaiwei; Suraneni, Praveen et al. (2018) A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis. Cancer Cell 34:707-723.e7 |
| Graves, Stephen; Seagle, Brandon-Luke L; Kocherginsky, Masha et al. (2018) Scholarship Support for Veterans Enrolling in MD, JD, and MBA Programs. JAMA 320:1197-1198 |
| Du, Jingshan S; Chen, Peng-Cheng; Meckes, Brian et al. (2018) Windowless Observation of Evaporation-Induced Coarsening of Au-Pt Nanoparticles in Polymer Nanoreactors. J Am Chem Soc 140:7213-7221 |
| Gao, Ruoqi; Piguel, Nicolas H; Melendez-Zaidi, Alexandria E et al. (2018) CNTNAP2 stabilizes interneuron dendritic arbors through CASK. Mol Psychiatry 23:1832-1850 |
| Greene, Jacqueline J; McClendon, Mark T; Stephanopoulos, Nicholas et al. (2018) Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair. J Tissue Eng Regen Med 12:1389-1401 |
| Stack, Trevor; Vahabikashi, Amir; Johnson, Mark et al. (2018) Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles. J Biomed Mater Res A 106:1771-1779 |
| Blair, Kris M; Mears, Kevin S; Taylor, Jennifer A et al. (2018) The Helicobacter pylori cell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton. Mol Microbiol 110:114-127 |
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