The University of California, Irvine Comprehensive Cancer Center is a matrix-type organization. The research goals of the Cancer Center are: 1) To contribute to understanding of the basic mechanisms that underlie the phenotype and genotype of cancer; 2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies; 3) To conduct clinical prevention trials. Whenever possible emanating from research generated in the Center; 4) To define cancer risk in the diverse socioeconomic and multi-cultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations; and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary research. The Cancer Center serves over 5 million people in Orange, Riverside, and San Bernardino Counties. Cancer Center members entered over 2000 participants or patients on prevention and treatment protocols in the year 2000. An extensive community research clinical trials network for gynecologic malignancies has been established in the Southern California region and beyond. A Clinical Trials Protocol Review and Monitoring System is functioning well. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control Research and Education and Training. The Divisions interact through eight research programs: Carcinogenesis, Growth Factors and Signaling, Developmental Biology, Virology, Translational Oncology, Photomedicine, and Population Sciences. The Center provides centralized support for these program functions through seven shared resource facilities: Biostatistics, Clinical Research Office, DNA Sequencing, Biomedical Protein and Mass Spectrometry, Optical Biology, Transgenic Mouse, and Viral Vectors. Three new shared resources are also proposed: Onco-Imaging, Microarray, and Translational Pathology. The Education and Training Division facilitates integration of students into basic, clinical, and control research activities in the various programs and accordingly enhances the translational capabilities of the Center. Developmental funds are used to recruit faculty in areas of research the Center has identified has high priority to provide seed grants that will support collaborative translational cancer research of Center members.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA062203-11
Application #
6745165
Study Section
Subcommittee G - Education (NCI)
Program Officer
Marino, Michael A
Project Start
1994-08-15
Project End
2007-01-31
Budget Start
2004-02-09
Budget End
2005-01-31
Support Year
11
Fiscal Year
2004
Total Cost
$2,599,237
Indirect Cost
Name
University of California Irvine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Koay, Eugene J; Lee, Yeonju; Cristini, Vittorio et al. (2018) A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24:5883-5894
Wilford, Justin; Osann, Kathryn; Hsieh, Susie et al. (2018) Validation of PROMIS emotional distress short form scales for cervical cancer. Gynecol Oncol 151:111-116
Bagaev, Alexander; Pichugin, Aleksey; Nelson, Edward L et al. (2018) Anticancer Mechanisms in Two Murine Bone Marrow-Derived Dendritic Cell Subsets Activated with TLR4 Agonists. J Immunol 200:2656-2669
Gong, Nian; Park, John; Luo, Z David (2018) Injury-induced maladaptation and dysregulation of calcium channel ?2 ? subunit proteins and its contribution to neuropathic pain development. Br J Pharmacol 175:2231-2243
Qiu, Xiaolong; Huang, Jen-Huang; Westerhof, Trisha M et al. (2018) Microfluidic channel optimization to improve hydrodynamic dissociation of cell aggregates and tissue. Sci Rep 8:2774
Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Zhu, Yong; Wang, Xiuye; Forouzmand, Elmira et al. (2018) Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Mol Cell 69:62-74.e4
Mishra, Birendra; Lawson, Gregory W; Ripperdan, Ryan et al. (2018) Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors. Radiat Res 190:142-150
Song, Wan; Zsindely, Nóra; Faragó, Anikó et al. (2018) Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease. Hum Mol Genet 27:649-666
Lin, Xiaoxiao; Itoga, Christy A; Taha, Sharif et al. (2018) c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress. Neurobiol Stress 8:92-102

Showing the most recent 10 out of 1106 publications