Abstract

The Biostatistics Shared Resource provides assistance with statistical aspects of experimental designs, data acquisition and database development, statistical analysis and interpretation of findings, collaboration on presentation of results, and development of new statistical procedures as required by specific projects within the Cancer Center. Over the past three years this resource has served at least 60 different Cancer Center investigators. Since September 1, 1995, when Dr. Shyr started as the Resource Biostatistician, over 25 investigator-initiated clinical trials have been designed, over 60 manuscripts have been published or submitted, about 40 abstracts have been delivered to the professional meetings and 3 Biostatistics Workshops have been provided to the members of Cancer Center. Dr. Shyr has served as the member of the Clinical Trial Shared Resource Steering Committee. He also has served as the member of the Clinical Protocol Review and Monitoring Committee (CPRMC) and reviewed more than 150 clinical protocols since 1995. The Shared Resource also has provided the maintenance of the clinical research database for the Cancer Center investigators and projects. This Resource will continue to provide high level of quality services to the Cancer Center investigators that have been established in the past three years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA068485-04
Application #
6232779
Study Section
Subcommittee G - Education (NCI)
Project Start
1995-09-05
Project End
2004-08-31
Budget Start
Budget End
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Burns, Michael C; Howes, Jennifer E; Sun, Qi et al. (2018) High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal Biochem 548:44-52
Phelps, Hannah M; Al-Jadiry, Mazin F; Corbitt, Natasha M et al. (2018) Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq. World J Pediatr 14:585-593
Liu, Qi; Herring, Charles A; Sheng, Quanhu et al. (2018) Quantitative assessment of cell population diversity in single-cell landscapes. PLoS Biol 16:e2006687
Almodovar, Karinna; Iams, Wade T; Meador, Catherine B et al. (2018) Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. J Thorac Oncol 13:112-123
Greenplate, Allison; Wang, Kai; Tripathi, Rati M et al. (2018) Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies. JCO Precis Oncol 2018:
Mi, Deborah J; Dixit, Shilpy; Warner, Timothy A et al. (2018) Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice. Neurobiol Aging 71:241-254
Diggins, Kirsten E; Gandelman, Jocelyn S; Roe, Caroline E et al. (2018) Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM). Curr Protoc Cytom 83:10.21.1-10.21.28
Warner, Jeremy L; Prasad, Ishaan; Bennett, Makiah et al. (2018) SMART Cancer Navigator: A Framework for Implementing ASCO Workshop Recommendations to Enable Precision Cancer Medicine. JCO Precis Oncol 2018:
Brown, Judy J; Short, Sarah P; Stencel-Baerenwald, Jennifer et al. (2018) Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J Virol 92:
Iams, Wade T; Yu, Hui; Shyr, Yu et al. (2018) First-line Chemotherapy Responsiveness and Patterns of Metastatic Spread Identify Clinical Syndromes Present Within Advanced KRAS Mutant Non-Small-cell Lung Cancer With Different Prognostic Significance. Clin Lung Cancer 19:531-543

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