Abstract

The Bioinformatics Shared Resource (BSR) of the HCCC meets an ever-expanding need from for services to HCCC members who seek to utilize large-volume data and analytical tools. The ongoing need for the BSR is evident from the number of HCCC investigators seeking BSR services and collaboration. BSR personnel actively participate in the NCI's Center for Biomedical Informatics and Information Technology (CBIIT) and National Cancer informatics Program (NCIP) activities. This facilitates their ability to help HCCC members identify tools from other cancer centers that may enhance their own research. The UI has made recent substantial investment in developing Informatics faculty and infrastructure with capabilities that complement the needs of the HCCC. The BSR maintains a collection of computing hardware and software, as well as the human expertise needed to support HCCC members in the design of experiments which require advanced analysis of genomic datasets, support in the deployment and use of existing informatics tools, and custom augmentation of existing tools to meet their needs. The BSR partners with the UI Center for Bioinformatics and Computational Biology (CBCB), as well as the Iowa Institute for Human Genetics (IIHG), to provide a conduit between diverse expertise, tools, and related bioinformatics research seeking to develop new translational research strategies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA086862-18
Application #
9460386
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Lorenzen, Allison W; Kiriazov, Boris; De Andrade, James P et al. (2018) Intraoperative Radiotherapy for Breast Cancer Treatment in a Rural Community. Ann Surg Oncol 25:3004-3010
Knight, Julia A; Blackmore, Kristina M; Fan, Jing et al. (2018) The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study. Breast Cancer Res 20:23
Peterson, Tabitha A; Stamnes, Mark A; Piper, Robert C (2018) A Yeast 2-Hybrid Screen in Batch to Compare Protein Interactions. J Vis Exp :
Erudaitius, Dieanira; Mantooth, Jacqueline; Huang, Andrew et al. (2018) Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy. Free Radic Biol Med 120:356-367
Pophali, Priyanka A; Ip, Andrew; Larson, Melissa C et al. (2018) The association of physical activity before and after lymphoma diagnosis with survival outcomes. Am J Hematol 93:1543-1550
Garcia-Monclús, Silvia; López-Alemany, Roser; Almacellas-Rabaiget, Olga et al. (2018) EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma. Int J Cancer 143:1188-1201
Towle, Tyrell R; Kulkarni, Chaitanya A; Oppegard, Lisa M et al. (2018) Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase. Bioorg Med Chem Lett 28:1903-1910
Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52
Link, Brian K; Day, Bann-Mo; Zhou, Xiaolei et al. (2018) Second-line and subsequent therapy and outcomes for follicular lymphoma in the United States: data from the observational National LymphoCare Study. Br J Haematol :
Monga, Varun; Swami, Umang; Tanas, Munir et al. (2018) A Phase I/II Study Targeting Angiogenesis Using Bevacizumab Combined with Chemotherapy and a Histone Deacetylase Inhibitor (Valproic Acid) in Advanced Sarcomas. Cancers (Basel) 10:

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